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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Ntrk3-EGFP)BM45Gsat
transgene insertion BM45, GENSAT Project at Rockefeller University
MGI:3831877
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Etv1tm2Tmj/Etv1tm2Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0 		involves: 129S1/Sv * FVB/N MGI:5506522
cx2
 		Plxna1tm1Tmj/Plxna1tm1Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0 		involves: 129S/SvEv * C57BL/6J * FVB/N MGI:3831890


Genotype
MGI:5506522
cx1
Allelic
Composition		 Etv1tm2Tmj/Etv1tm2Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0
Genetic
Background		 involves: 129S1/Sv * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Etv1tm2Tmj mutation (0 available); any Etv1 mutation (44 available)
Tg(Ntrk3-EGFP)BM45Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal axon guidance ( J:197913 )
• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls

nervous system
abnormal axon guidance ( J:197913 )
• in P5-6 mutants, almost complete depletion in the laterally-targeted pSN axon fascicle at T9, L2 and L5 spinal cord levels; medially-oriented pSN axons are greatly reduced in number at all segmental levels compared to controls
decreased sensory neuron number ( J:197913 )
• number of proprioceptive sensory neurons (pSNs) detected in DRGs at level of L2 are decreased by 30% at P0 and by P10, there is 80% loss; at L5 levels, pSN number is decreased by 40% at P0 and P10




Genotype
MGI:3831890
cx2
Allelic
Composition		 Plxna1tm1Tmj/Plxna1tm1Tmj
Tg(Ntrk3-EGFP)BM45Gsat/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Plxna1tm1Tmj mutation (0 available); any Plxna1 mutation (75 available)
Tg(Ntrk3-EGFP)BM45Gsat mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal proprioceptive neuron morphology ( J:144660 )
• from E12.5 to E16.5, the proprioceptive axons are displaced into the neuropil of the dorsal spinal cord unlike in wild-type mice
• from P0 to P8, over 95% of displaced proprioceptive axons shaft located in the medial half of the superficial dorsal horn unlike in wild-type mice, and the incidence of proprioceptive axon shafts within the medial half of the dorsal funiculus is decreased 95% compared to in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory