Phenotypes associated with this allele

• Allele Symbol: mt-Tr^m1
• Allele Name: mutation 1
• Allele ID: MGI:3831887
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Cdh23^ahl/Cdh23^ahl mt-Tr^m1	either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1	MGI:3831893
cx2	Cs^ahl4/Cs^ahl4 mt-Tr^m1/mt-Tr^m1	involves: A/J * C57BL/6J	MGI:6121364

Genotype
MGI:3831893

cx1

• Allelic Composition: Cdh23^ahl/Cdh23^ahl; mt-Tr^m1
• Genetic Background: either: A/J X (A/J x CAST/Ei)F1 or A/J X (CAST/Ei x A/J)F1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:67312 )

• average ABR threshold is significantly increased by 3 months of age

increased susceptibility to age-related hearing loss ( J:67312 )

• the presence of this mitochondrial sequence polymorphism in mice homozygous for the ahl allele results in age related hearing loss by 3 months of age, which is absent when the CAST/Ei mitochondrial sequence is instead present

Genotype
MGI:6121364

cx2

• Allelic Composition: Cs^ahl4/Cs^ahl4; mt-Tr^m1/mt-Tr^m1
• Genetic Background: involves: A/J * C57BL/6J

hearing/vestibular/ear

increased or absent threshold for auditory brainstem response ( J:188196 )

• compared with Cs^ahl4 homozygotes with mitochondria originating from C57BL/6