All Phenotypes Dvl3<tm1Awb> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dvl3^tm1Awb
targeted mutation 1, Anthony Wynshaw-Boris
MGI:3831892

Summary

14 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dvl3^tm1Awb/Dvl3^tm1Awb	129S6/SvEvTac-Dvl3^tm1Awb	MGI:3831915
hm2	Dvl3^tm1Awb/Dvl3^tm1Awb	involves: 129S6/SvEvTac * Black Swiss	MGI:3831916
cn3	Dvl3^tm1Awb/Dvl3^tm1Awb Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Isl1^tm1(cre)Sev/Isl1⁺	involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss	MGI:3831923
cn4	Dvl3^tm1Awb/Dvl3^tm1Awb Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺	involves: 129S/Sv * Black Swiss * C57BL/6J * CBA/J	MGI:3831922
cx5	Dvl3^tm1Awb/Dvl3⁺ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat	involves: 129 * C57BL/6	MGI:5444710
cx6	Dvl3^tm1Awb/Dvl3^tm1Awb Fzd7^tm1.1Nat/Fzd7^tm1.1Nat	involves: 129 * C57BL/6	MGI:5444712
cx7	Dvl3^tm1Awb/Dvl3⁺ Fzd2^tm1.1Nat/Fzd2⁺ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat	involves: 129 * C57BL/6	MGI:5444711
cx8	Dvl3^tm1Awb/Dvl3⁺ Vangl2^Lp/Vangl2⁺	involves: 129S6/SvEvTac * A * Black Swiss	MGI:3831924
cx9	Dvl3^tm1Awb/Dvl3^tm1Awb Vangl2^Lp/Vangl2⁺	involves: 129S6/SvEvTac * A * Black Swiss	MGI:3831926
cx10	Dvl2^tm1Awb/Dvl2⁺ Dvl3^tm1Awb/Dvl3⁺	involves: 129S6/SvEvTac * Black Swiss	MGI:3831932
cx11	Dvl1^tm1Awb/Dvl1^tm1Awb Dvl3^tm1Awb/Dvl3^tm1Awb	involves: 129S6/SvEvTac * Black Swiss	MGI:3831928
cx12	Dvl2^tm1Awb/Dvl2^tm1Awb Dvl3^tm1Awb/Dvl3⁺	involves: 129S6/SvEvTac * Black Swiss	MGI:3831929
cx13	Dvl2^tm1Awb/Dvl2^tm1Awb Dvl3^tm1Awb/Dvl3^tm1Awb	involves: 129S6/SvEvTac * Black Swiss	MGI:3831930
cx14	Dvl2^tm1Awb/Dvl2⁺ Dvl3^tm1Awb/Dvl3^tm1Awb	involves: 129S6/SvEvTac * Black Swiss	MGI:3831931

Allelic Composition	Dvl3^tm1Awb/Dvl3^tm1Awb
Genetic Background	129S6/SvEvTac-Dvl3^tm1Awb

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:142392 )

• despite being present in Mendelian ratios at E18.5, no mice survive to weaning

• however, survival can be rescued by expression of a Dvl1, Dvl2, or Dvl3 transgene

cardiovascular system

persistent truncus arteriosus ( J:142392 )

• in 7 of 11 mice

double outlet right ventricle ( J:142392 )

• in 4 of 11 mice

homeostasis/metabolism

cyanosis ( J:142392 )

• at birth

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

skeleton

split xiphoid process ( J:142392 )

• some mice exhibit xiphoid bifircation also observed in some wild-type mice

respiratory system

respiratory distress ( J:142392 )

• at birth

nervous system

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

Allelic Composition	Dvl3^tm1Awb/Dvl3^tm1Awb
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:142392 )

• however, survival can be rescued by expression of a Dvl1, Dvl2, or Dvl3 transgene

• Background Sensitivity: despite being present in Mendelian ratios at E18.5, only 4 of the expected 30 mice survive to weaning compared to no mice surviving on a pure 129S6/SvEvTac background

cardiovascular system

persistent truncus arteriosus ( J:142392 )

• in 7 of 11 mice

double outlet right ventricle ( J:142392 )

• in 4 of 11 mice

homeostasis/metabolism

cyanosis ( J:142392 )

• at birth

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

skeleton

split xiphoid process ( J:142392 )

• some mice exhibit xiphoid bifircation also observed in some wild-type mice

respiratory system

respiratory distress ( J:142392 )

• at birth

nervous system

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

Allelic Composition	Dvl3^tm1Awb/Dvl3^tm1Awb Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Isl1^tm1(cre)Sev/Isl1⁺
Genetic Background	involves: 129S4/SvJaeSor * 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
Isl1^tm1(cre)Sev mutation (1 available); any Isl1 mutation (36 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

cardiovascular system phenotype ( J:142392 )

N	• at E10.5, E14.5 and E18.5, secondary heart field development is normal

Allelic Composition	Dvl3^tm1Awb/Dvl3^tm1Awb Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ H2az2^{Tg(Wnt1-cre)11Rth}/H2az2⁺
Genetic Background	involves: 129S/Sv * Black Swiss * C57BL/6J * CBA/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)
Gt(ROSA)26Sor^tm1Sor mutation (7 available); any Gt(ROSA)26Sor mutation (993 available)
H2az2^{Tg(Wnt1-cre)11Rth} mutation (2 available); any H2az2 mutation (26 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:142392 )

N	• at E10.5, E14.5 and E18.5, cardiac neural crest cell development is normal

Allelic Composition	Dvl3^tm1Awb/Dvl3⁺ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)
Fzd7^tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:189062 )

• 50% of embryos (n=14) display cardiac defects

ventricular septal defect ( J:189062 )

• most defects are VSDs

Allelic Composition	Dvl3^tm1Awb/Dvl3^tm1Awb Fzd7^tm1.1Nat/Fzd7^tm1.1Nat
Genetic Background	involves: 129 * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:189062 )

• all (3 of 3) embryos display cardiac defects

ventricular septal defect ( J:189062 )

• most defects are VSDs

Allelic Composition	Dvl3^tm1Awb/Dvl3⁺ Fzd2^tm1.1Nat/Fzd2⁺ Fzd7^tm1.1Nat/Fzd7^tm1.1Nat
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)
Fzd2^tm1.1Nat mutation (1 available); any Fzd2 mutation (34 available)
Fzd7^tm1.1Nat mutation (1 available); any Fzd7 mutation (37 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal heart morphology ( J:189062 )

• 83% of embryos (n=12) display cardiac defects

ventricular septal defect ( J:189062 )

• most defects are VSDs

Allelic Composition	Dvl3^tm1Awb/Dvl3⁺ Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129S6/SvEvTac * A * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)
Vangl2^Lp mutation (2 available); any Vangl2 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:142392 )

• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly

incomplete rostral neuropore closure ( J:142392 )

• some mice develop defects in rostral neural tube closure

craniorachischisis ( J:142392 )

• in 5 of 22 mice

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

exencephaly ( J:142392 )

• in 2 of 22 mice

cardiovascular system

cardiovascular system phenotype ( J:142392 )

N	• hearts develop normally

hearing/vestibular/ear

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of cochlear hair cell stereociliary bundles in mice with neural tube defects is disrupted in the base and middle of the cochlear ducts

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

inner ear hypoplasia ( J:142392 )

• in mice with neural tube defects

embryo

abnormal neural tube morphology ( J:142392 )

• some mice develop neural tube abnormalities such as craniorachischisis and exencephaly

incomplete rostral neuropore closure ( J:142392 )

• some mice develop defects in rostral neural tube closure

craniorachischisis ( J:142392 )

• in 5 of 22 mice

Allelic Composition	Dvl3^tm1Awb/Dvl3^tm1Awb Vangl2^Lp/Vangl2⁺
Genetic Background	involves: 129S6/SvEvTac * A * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal neural tube morphology ( J:142392 )

• some mice develop similar neural tube defects as in Dvl3^tm1Awb Vangl2^Lp double heterozygotes

craniorachischisis ( J:142392 )

• in 6 of 16 mice

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• mice with neural tube defects exhibit more severe orientation defects than in mice with normal neural tube closure

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

cardiovascular system

abnormal cardiac outflow tract development ( J:142392 )

• mice exhibit conotruncal defects

hearing/vestibular/ear

decreased cochlear outer hair cell number ( J:142392 )

• some mice exhibit a loss of outer hair cell rows compared to in wild-type mice along 5% to 20% of the cochlear length

increased cochlear hair cell number ( J:142392 )

• some mice exhibit additional rows of outer and inner cells in the apical region of the cochlea compared to in wild-type mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• the orientation of many cochlear hair cell stereociliary bundles is disrupted in the base and middle of the cochlear ducts

• mice with neural tube defects exhibit more severe orientation defects than in mice with normal neural tube closure

• stereociliary bundles in apical regions are rotated compared to in wild-type mice

inner ear hypoplasia ( J:142392 )

• in mice with neural tube defects

embryo

abnormal neural tube morphology ( J:142392 )

• some mice develop similar neural tube defects as in Dvl3^tm1Awb Vangl2^Lp double heterozygotes

craniorachischisis ( J:142392 )

• in 6 of 16 mice

Allelic Composition	Dvl2^tm1Awb/Dvl2⁺ Dvl3^tm1Awb/Dvl3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl2^tm1Awb mutation (1 available); any Dvl2 mutation (35 available)
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

abnormal cardiac outflow tract development ( J:142392 )

• at E18.5, 11 of 28 mice exhibit conotruncal defects

persistent truncus arteriosus ( J:142392 )

• in 1 of 11 mice

double outlet right ventricle ( J:142392 )

• in 9 of 11 mice

transposition of great arteries ( J:142392 )

• in 1 of 11 mice

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

nervous system

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

Allelic Composition	Dvl1^tm1Awb/Dvl1^tm1Awb Dvl3^tm1Awb/Dvl3^tm1Awb
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dvl1^tm1Awb mutation (2 available); any Dvl1 mutation (35 available)
Dvl3^tm1Awb mutation (1 available); any Dvl3 mutation (38 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:142392 )

• mice die between E13.5 and E15.5

nervous system

nervous system phenotype ( J:142392 )

N	• mice exhibit normal neural tube development

Allelic Composition	Dvl2^tm1Awb/Dvl2^tm1Awb Dvl3^tm1Awb/Dvl3⁺
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:142392 )

• die by E9.5

cardiovascular system

abnormal heart looping ( J:142392 )

pericardial effusion ( J:142392 )

embryo

caudal body truncation ( J:142392 )

craniorachischisis ( J:142392 )

nervous system

craniorachischisis ( J:142392 )

homeostasis/metabolism

pericardial effusion ( J:142392 )

Allelic Composition	Dvl2^tm1Awb/Dvl2^tm1Awb Dvl3^tm1Awb/Dvl3^tm1Awb
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:142392 )

• mice die prior to E8.5

Allelic Composition	Dvl2^tm1Awb/Dvl2⁺ Dvl3^tm1Awb/Dvl3^tm1Awb
Genetic Background	involves: 129S6/SvEvTac * Black Swiss

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

persistent truncus arteriosus ( J:142392 )

abnormal heart shape ( J:142392 )

• at P0

small heart ( J:142392 )

• at P0

craniofacial

short snout ( J:142392 )

embryo

short rostral-caudal axis ( J:142392 )

• at E18.5, mice exhibit shortening along the anterior-posterior axis

craniorachischisis ( J:142392 )

• in two mice

growth/size/body

herniated abdominal wall ( J:142392 )

• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

abnormal head morphology ( J:142392 )

short snout ( J:142392 )

hearing/vestibular/ear

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice

• defects are more severe in mice also displaying craniorachischisis

limbs/digits/tail

short tail ( J:142392 )

absent tail ( J:142392 )

• one mouse exhibited craniorachischisis, gastroschisis, and an absent tail

kinked tail ( J:142392 )

nervous system

craniorachischisis ( J:142392 )

• in two mice

abnormal orientation of cochlear hair cell stereociliary bundles ( J:142392 )

• mice exhibit rotated stereocillia bundles and mild patterning defects compared to in wild-type mice

• defects are more severe in mice also displaying craniorachischisis

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