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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Scgb1a1-Il13)2Eli
transgene insertion 2, Jack A Elias
MGI:3832264
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3832413
cx2
 		Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/? 		involves: 129S2/SvPas * C57BL/6 * CBA MGI:3832414
cx3
 		Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/? 		involves: 129S2/SvPas * C57BL/6 * CBA * FVB MGI:3832416
cx4
 		Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0 		involves: C57BL/6 * CBA MGI:5447953
tg5
 		Tg(Scgb1a1-Il13)2Eli/? involves: C57BL/6 * CBA MGI:3832412


Genotype
MGI:3832413
cx1
Allelic
Composition		 Stat6tm1Gru/Stat6+
Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system morphology ( J:132385 )
• substantial epithelial fibrosis occurs
abnormal lung morphology ( J:132385 )
• discolored lungs
abnormal lung size ( J:132385 )
• distended lungs
abnormal pulmonary alveolus morphology ( J:132385 )
• alveolar tissue destruction
overexpanded pulmonary alveolus ( J:132385 )
• alveoli are enlarged
abnormal respiratory system physiology ( J:132385 )
• develop airway hyper reactivity
• increased mucus production
respiratory system inflammation ( J:132385 )
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles

immune system
respiratory system inflammation ( J:132385 )
• bronchoalveolar lavage contains increased numbers of macrophage, eosinophiles, lymphocytes, and neutrophiles




Genotype
MGI:3832414
cx2
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:132385 )
N
• do not develop airway hyper reactivity
• normal mucus production
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal




Genotype
MGI:3832416
cx3
Allelic
Composition		 Stat6tm1Gru/Stat6tm1Gru
Tg(Scgb1a1-Il13)2Eli/?
Tg(Scgb1a1-STAT6)1Erle/?
Genetic
Background		 involves: 129S2/SvPas * C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Stat6tm1Gru mutation (4 available); any Stat6 mutation (53 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
Tg(Scgb1a1-STAT6)1Erle mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
respiratory system phenotype ( J:132385 )
N
• no proinflamatory effects
• no airway epithelium fibrosis
• lung morphology normal
abnormal respiratory system physiology ( J:132385 )
• develop airway hyper reactivity
• increased mucus production




Genotype
MGI:5447953
cx4
Allelic
Composition		 Chit1tm1Eli/Chit1tm1Eli
Tg(Scgb1a1-Il13)2Eli/0
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Chit1tm1Eli mutation (0 available); any Chit1 mutation (32 available)
Tg(Scgb1a1-Il13)2Eli mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased susceptibility to bacterial infection ( J:189872 )
• bleomycin-treated mice exhibit reduced pulmonary fibrosis and inflammation compared with control mice




Genotype
MGI:3832412
tg5
Allelic
Composition		 Tg(Scgb1a1-Il13)2Eli/?
Genetic
Background		 involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system morphology ( J:53612 )
• nuclear enlargement in airway epithelial cells
• airway epithelial cell hypertrophy
• intracellular accumulation of refractile materials in epithelium
• increased collagen deposition in subepithelial regions and in the adventitia of the airways
abnormal pulmonary alveolus morphology ( J:53612 )
• accumulation of needlelike crystals in alveoli and air passages, increasing with age
abnormal pulmonary alveolus wall morphology ( J:53612 )
• alveolar wall rupture observed
abnormal respiratory system physiology ( J:53612 )
• production of neutral and acidic mucus stimulated
respiratory system inflammation ( J:53612 )
• inflammatory response around small and large airways and in neighboring parenchyma
• milder in 1-2 month old mice
• more pronounced in 2-4 month old mice
increased airway resistance ( J:53612 )
• increased baseline airway resistance particularly as mice age
increased airway responsiveness ( J:53612 )
• increased bronchiospastic response to methacholine

immune system
abnormal leukocyte physiology ( J:53612 )
• cells involved in respiratory inflammation predominantly mononuclear
• moderate numbers of enlarged and sometimes multinucleated macrophage
• significant numbers of eosinophiles
• pockets of degenerating inflammatory cells
respiratory system inflammation ( J:53612 )
• inflammatory response around small and large airways and in neighboring parenchyma
• milder in 1-2 month old mice
• more pronounced in 2-4 month old mice

hematopoietic system
abnormal leukocyte physiology ( J:53612 )
• cells involved in respiratory inflammation predominantly mononuclear
• moderate numbers of enlarged and sometimes multinucleated macrophage
• significant numbers of eosinophiles
• pockets of degenerating inflammatory cells




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory