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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Npsr1tm1Bhk
targeted mutation 1, Beverly H Koller
MGI:3832372
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Npsr1tm1Bhk/Npsr1tm1Bhk 129S/SvEv-Npsr1tm1Bhk MGI:3832383
hm2
 		Npsr1tm1Bhk/Npsr1tm1Bhk either: (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6) MGI:3832382


Genotype
MGI:3832383
hm1
Allelic
Composition		 Npsr1tm1Bhk/Npsr1tm1Bhk
Genetic
Background		 129S/SvEv-Npsr1tm1Bhk
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npsr1tm1Bhk mutation (2 available); any Npsr1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
decreased airway resistance ( J:144688 )
• at high concentrations of U-46619, mice exhibit decreased airway resistance compared to in wild-type mice

immune system
immune system phenotype ( J:144688 )
N
• despite involvement of the gene in asthma susceptibility, mice exhibit normal immune system morphology and physiology

homeostasis/metabolism
abnormal physiological response to xenobiotic ( J:144688 )
• at high concentrations of U-46619, mice exhibit decreased airway resistance compared to in wild-type mice




Genotype
MGI:3832382
hm2
Allelic
Composition		 Npsr1tm1Bhk/Npsr1tm1Bhk
Genetic
Background		 either: (involves: 129S6/SvEvTac * BALB/c) or (involves: 129S6/SvEvTac * C57BL/6)
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Npsr1tm1Bhk mutation (2 available); any Npsr1 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:144688 )
N
• despite involvement of the gene in asthma susceptibility, mice exhibit normal immune system morphology and physiology




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory