Analysis Tools|
Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm3(HIF1A*)Kael targeted mutation 3, William G Kaelin MGI:3832385 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• mice exhibit a normal life span
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• hepatocytes exhibit fine vacuolization unlike in wild-type mice but are otherwise normal
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• moderate and in a microvesicular pattern
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice die at 6 to 8 weeks of age
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• at 6 weeks, the liver is friable and stippled with irregular yellow spots on a reddish black background unlike in wild-type mice
• hepatic vascularity is increased compared to in wild-type mice
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• at 6 weeks of age
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• in a mixed micro- and macrovesicular steatotic pattern
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• hepatic vascularity is increased compared to in wild-type mice
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| N |
• unlike in Vhltm1Jae/Vhltm1Jae Tg(Alb-cre)21Mgn mice, body weight is normal
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• at 6 weeks of age
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• of paws and unfurred skin by 4 to 6 weeks of age
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 12/10/2024 MGI 6.24 |
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