Phenotypes associated with this allele

• Allele Symbol: Ldb3^tm4Chen
• Allele Name: targeted mutation 4, Ju Chen
• Allele ID: MGI:3832388
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Ldb3^tm4Chen/Ldb3^tm4Chen Myl2^tm1(cre)Krc/Myl2^+	involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss	MGI:3832389
cn2	Ldb3^tm4Chen/Ldb3^tm4Chen A1cf^Tg(Myh6-cre/Esr1*)1Jmk/A1cf^+	involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N	MGI:3832390

Genotype
MGI:3832389

cn1

• Allelic Composition: Ldb3^tm4Chen/Ldb3^tm4Chen; Myl2^tm1(cre)Krc/Myl2⁺
• Genetic Background: involves: 129S1/Sv * 129S4/SvJae * 129X1/SvJ * Black Swiss

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:144739 )

• all die between 16 and 23 weeks of age

cardiovascular system

abnormal myocardial fiber morphology ( J:144739 )

• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen

• however M-lines are relatively normal

enlarged heart ( J:144739 )

• enlarged left and right ventricles

increased heart weight ( J:144739 )

• the ratios of heart weight to body weight and heart weight to tibia bone length are increased

cardiac hypertrophy ( J:144739 )

abnormal heart ventricle morphology ( J:144739 )

thin interventricular septum ( J:144739 )

• thinner at end diastole compared to controls

abnormal heart left ventricle morphology ( J:144739 )

• significant increase in left ventricular dimension at end diastole and end systole

• enlarged with a thinner wall

• increase in left ventricle size is seen in mice at 2 - 4 months of age but not at 1 month of age

abnormal heart right ventricle morphology ( J:144739 )

• enlarged with a thinner wall

thin ventricular wall ( J:144739 )

• in both the left and right ventricles

dilated cardiomyopathy ( J:144739 )

atrioventricular block ( J:144739 )

• electrocardiography reveals an atrioventricular block

muscle

abnormal myocardial fiber morphology ( J:144739 )

• Z-lines in 3 month old mice are severely disrupted and disorganized and abnormal mitochondria are seen

• however M-lines are relatively normal

dilated cardiomyopathy ( J:144739 )

growth/size/body

enlarged heart ( J:144739 )

• enlarged left and right ventricles

increased heart weight ( J:144739 )

• the ratios of heart weight to body weight and heart weight to tibia bone length are increased

cardiac hypertrophy ( J:144739 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1C		DOID:0110423	OMIM:601493	J:144739

Genotype
MGI:3832390

cn2

• Allelic Composition: Ldb3^tm4Chen/Ldb3^tm4Chen; A1cf^{Tg(Myh6-cre/Esr1*)1Jmk}/A1cf⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * Black Swiss * FVB/N

mortality/aging

premature death ( J:144739 )

• all mice die between 1 and 16 weeks after tamoxifen treatment

cardiovascular system

enlarged heart ( J:144739 )

• after tamoxifen treatment

dilated heart left ventricle ( J:144739 )

• both ventricles are severely dilated after tamoxifen treatment

dilated heart right ventricle ( J:144739 )

• both ventricles are severely dilated after tamoxifen treatment

abnormal cardiovascular system physiology ( J:144739 )

• decreased heart function one month after tamoxifen treatment

dilated cardiomyopathy ( J:144739 )

• after tamoxifen treatment

muscle

dilated cardiomyopathy ( J:144739 )

• after tamoxifen treatment

growth/size/body

enlarged heart ( J:144739 )

• after tamoxifen treatment

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
dilated cardiomyopathy 1C		DOID:0110423	OMIM:601493	J:144739