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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rad50tm3Jpt
targeted mutation 3, John H J Petrini
MGI:3832533
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Rad50tm3Jpt/Rad50tm4.1Jpt 		involves: 129/Sv * C57BL/6 MGI:5614075
cn2
 		Rad50tm1Jpt/Rad50tm3Jpt
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+ 		involves: 129/Sv * C57BL/6 MGI:5614076
cn3
 		Rad50tm1Jpt/Rad50tm3Jpt
Tg(Pcp2-cre)2Mpin/0 		involves: 129S7/SvEvBrd * C57BL/6 MGI:3832543
cn4
 		Rad50tm1Jpt/Rad50tm3Jpt
Tg(Mx1-cre)1Cgn/0 		involves: 129S7/SvEvBrd * C57BL/6 * CBA MGI:3832542


Genotype
MGI:5614075
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Rad50tm3Jpt/Rad50tm4.1Jpt
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Rad50tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:209141 )
• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system
abnormal intestine morphology ( J:209141 )
• intestinal defects are seen by day 9 of tamoxifen treatment
• die of intestinal failure




Genotype
MGI:5614076
cn2
Allelic
Composition		 Rad50tm1Jpt/Rad50tm3Jpt
Gt(ROSA)26Sortm1(cre/ERT2)Tyj/Gt(ROSA)26Sor+
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation (3 available); any Gt(ROSA)26Sor mutation (993 available)
Rad50tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
postnatal lethality, complete penetrance ( J:209141 )
• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system
abnormal intestine morphology ( J:209141 )
• intestinal defects are seen by day 9 of tamoxifen treatment
• die of intestinal failure




Genotype
MGI:3832543
cn3
Allelic
Composition		 Rad50tm1Jpt/Rad50tm3Jpt
Tg(Pcp2-cre)2Mpin/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
abnormal gait ( J:144766 )
• minor

nervous system
nervous system phenotype ( J:144766 )
N
• mice exhibit normal nervous system morphology with no increase in DNA damage




Genotype
MGI:3832542
cn4
Allelic
Composition		 Rad50tm1Jpt/Rad50tm3Jpt
Tg(Mx1-cre)1Cgn/0
Genetic
Background		 involves: 129S7/SvEvBrd * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
liver/biliary system
decreased hepatocyte proliferation ( J:144766 )
• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage
• however, a subset of hepatocytes resolve their DNA damage and divide
abnormal hepatocyte morphology ( J:144766 )
• while liver regeneration following partial hepatectomy is normal, pIpC-treated hepatocytes exhibit an increase in DNA damage compared to wild-type cells
• however, a subset of hepatocytes resolve their DNA damage and divide
liver hypoplasia ( J:144766 )
• following partial hepatectomy, pIpC-treated livers exhibit reduced cellularity and endoreduplication compared to in similarly-treated wild-type mice

hematopoietic system
decreased bone marrow cell number ( J:144766 )
• the only viable bone marrow left after treatment with pIpC fails to exhibit recombination

cellular
decreased hepatocyte proliferation ( J:144766 )
• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage
• however, a subset of hepatocytes resolve their DNA damage and divide




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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory