Phenotypes associated with this allele

• Allele Symbol: Casp12^tm1Dwni
• Allele Name: targeted mutation 1, Donald W Nicholson
• Allele ID: MGI:3832547
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Casp12^tm1Dwni/Casp12^tm1Dwni	involves: 129S1/SvImJ * C57BL/6	MGI:3832548

Genotype
MGI:3832548

hm1

• Allelic Composition: Casp12^tm1Dwni/Casp12^tm1Dwni
• Genetic Background: involves: 129S1/SvImJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:144912 )

• 60% of mice survive longer than 48 hours in the colon ascendens stent peritonitis (CASP) model of sepsis compared to about 20 for wild-type controls

• antibodies that neutralize IFN-gamma receptors negate the sepsis resistance of mice

immune system

increased circulating interleukin-18 level ( J:144912 )

• splenocytes produce more IL-18 in response to culturing with resiquimod or CpG

increased interferon-gamma secretion ( J:144912 )

• splenocytes produce more IFN-gamma in response to culturing with CpG

increased interleukin-1 beta secretion ( J:144912 )

• splenocytes produce more IL1-beta in response to culturing with LPS

increased susceptibility to endotoxin shock ( J:144912 )

• 90% of mice die from LPS overdose indicating they lack the resistance to endotoxic shock that are characteristic for Casp4^tm1Yuan homozygotes

decreased susceptibility to bacterial infection ( J:144912 )

• 12 hours after induction of sepsis, mice have two log units lower number of bacteria in their blood compared to controls

• chimeric bone marrow studies demonstrate the protective effect of the mutant allele depends on both haematopoietic and non-haematopoietic derived cells

• mice also have enhanced clearance of Listeria monocytogenes pathogen

• bacterial counts in the spleen mice infected with L. monocytogenes are 1 to 2 log units lower than controls from 1 to 4 days after infection

• bacterial counts in the liver are 1 to 3 log units lower 3 or 4 days after infection

decreased susceptibility to bacterial infection induced morbidity/mortality ( J:144912 )

• 60% of mice survive longer than 48 hours in the colon ascendens stent peritonitis (CASP) model of sepsis compared to about 20 for wild-type controls

• antibodies that neutralize IFN-gamma receptors negate the sepsis resistance of mice

homeostasis/metabolism

increased circulating interleukin-18 level ( J:144912 )

• splenocytes produce more IL-18 in response to culturing with resiquimod or CpG