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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(REN)64071Sig
transgene insertion 64701, Curt Sigmund
MGI:3832666
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Hprt1tm1(AGT)Asku/Y
Tg(REN)64071Sig/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:3832677
cx2
 		Hprt1tm2(AGT)Asku/Y
Tg(REN)64071Sig/? 		involves: 129P2/OlaHsd * C57BL/6 MGI:3832678


Genotype
MGI:3832677
cx1
Allelic
Composition		 Hprt1tm1(AGT)Asku/Y
Tg(REN)64071Sig/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm1(AGT)Asku mutation (0 available); any Hprt1 mutation (1279 available)
Tg(REN)64071Sig mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating angiotensin II level ( J:143791 )
• plasma levels of angiotensin II are increased 80% over non-transgenic controls
abnormal protein level ( J:143791 )
• liver levels of angiotensinogen are 1.62 fold higher than mice of the AG haplotype
• kidney levels of angiotensinogen are 1.45 fold higher than mice of the AG haplotype
abnormal circulating angiotensinogen level ( J:143791 )
• plasma levels are increased 40-50% relative to mice of the AG haplotype

cardiovascular system
increased systemic arterial systolic blood pressure ( J:143791 )
• blood pressure in males measured at 3 months of age is 125mm Hg compared to 111mm Hg in non-transgenic controls




Genotype
MGI:3832678
cx2
Allelic
Composition		 Hprt1tm2(AGT)Asku/Y
Tg(REN)64071Sig/?
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hprt1tm2(AGT)Asku mutation (0 available); any Hprt1 mutation (1279 available)
Tg(REN)64071Sig mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating angiotensin II level ( J:143791 )
• plasma levels of angiotensin II are increased 40% over non-transgenic controls
abnormal protein level ( J:143791 )
• liver levels of angiotensinogen are lower than mice of the AA haplotype
• kidney levels of angiotensinogen are lower than mice of the AA haplotype
abnormal circulating angiotensinogen level ( J:143791 )
• plasma levels are less than in mice of the AG haplotype

cardiovascular system
increased systemic arterial systolic blood pressure ( J:143791 )
• blood pressure in males measured at 3 months of age is 117mm Hg compared to 111mm Hg in non-transgenic controls




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory