Phenotypes associated with this allele

• Allele Symbol: Hprt1^tm1(AGT)Asku
• Allele Name: targeted mutation 1, Ashok Kumar
• Allele ID: MGI:3832668
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Hprt1^tm1(AGT)Asku/Y Tg(REN)64071Sig/?	involves: 129P2/OlaHsd * C57BL/6	MGI:3832677

Genotype
MGI:3832677

cx1

• Allelic Composition: Hprt1^tm1(AGT)Asku/Y; Tg(REN)64071Sig/?
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating angiotensin II level ( J:143791 )

♂ • plasma levels of angiotensin II are increased 80% over non-transgenic controls

abnormal protein level ( J:143791 )

♂ • liver levels of angiotensinogen are 1.62 fold higher than mice of the AG haplotype

♂ • kidney levels of angiotensinogen are 1.45 fold higher than mice of the AG haplotype

abnormal circulating angiotensinogen level ( J:143791 )

♂ • plasma levels are increased 40-50% relative to mice of the AG haplotype

cardiovascular system

increased systemic arterial systolic blood pressure ( J:143791 )

♂ • blood pressure in males measured at 3 months of age is 125mm Hg compared to 111mm Hg in non-transgenic controls