Analysis Tools
hearing/vestibular/ear
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• inner hair cells from mice 6 to 10 days old are more sensitive to acetylcholine (ACH) in voltage clamp studies with EC-50 values being less than half of controls
• ACh-evoked membrane current was more sustained than that seen in wild-type mice
• spontaneous inhibitory postsynaptic currents (sIPSC) are dramatically prolonged in these mice with a 6-fold increase in decay and a 3-fold increase in the duration at half amplitude under conditions that test for "acetylcholine receptor only" currents
• sIPSC are also dramatically prolonged under more standard conditions
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• outer hair cells have prolonged inhibitory postsynaptic currents (sIPSC) compared to controls when currents are invoked by potassium with the area under the curve being twice as large compared to controls
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• mean ABR thresholds are elevated by 5-15 dB compared to controls
• threshold shifts are larger at frequencies above 16 kHz
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• mean DPOAEs thresholds are elevated by 5-15 dB compared to controls
• wild-type mice have a brief suppression of DPOAE in response to electrical shocking of the medial olivocochlear efferents (MOC) but recover to baseline levels even with subsequent shocking
• mutant mice have a much slower onset of DPOAE suppression but suppression continues to grow with subsequent shocks until no longer detected
• DPOE does not return until about 3 minutes after MOC shocking
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• mice are resistant to permanent hearing loss induced by a 8-16-kHz noise band at 100 dB for 2 hours
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nervous system
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• inner hair cells from mice 6 to 10 days old are more sensitive to acetylcholine (ACH) in voltage clamp studies with EC-50 values being less than half of controls
• ACh-evoked membrane current was more sustained than that seen in wild-type mice
• spontaneous inhibitory postsynaptic currents (sIPSC) are dramatically prolonged in these mice with a 6-fold increase in decay and a 3-fold increase in the duration at half amplitude under conditions that test for "acetylcholine receptor only" currents
• sIPSC are also dramatically prolonged under more standard conditions
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• outer hair cells have prolonged inhibitory postsynaptic currents (sIPSC) compared to controls when currents are invoked by potassium with the area under the curve being twice as large compared to controls
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• spontaneous inhibitory postsynaptic currents (sIPSC) of neonate inner hair cells are dramatically prolonged in these mice with a 6-fold increase in decay and a 3-fold increase in the duration at half amplitude under conditions that test for Acetylcholine receptor only currents
• sIPSC were also dramatically prolonged under more standard conditions
• outer hair cells also have prolonged sIPSC when currents are invoked by potassium with the area under the curve being twice as large compared to controls
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