Phenotypes associated with this allele

• Allele Symbol: Lipe^tm2Rze
• Allele Name: targeted mutation 2, Rudolf Zechner
• Allele ID: MGI:3832721
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Lipe^tm2Rze/Lipe^tm2Rze Tg(Ins2-cre)25Mgn/?	involves: 129 * C57BL/6 * DBA	MGI:3833129

Genotype
MGI:3833129

cn1

• Allelic Composition: Lipe^tm2Rze/Lipe^tm2Rze; Tg(Ins2-cre)25Mgn/?
• Genetic Background: involves: 129 * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating leptin level ( J:144744 )

• 3.5 fold increase in plasma leptin

abnormal glucose homeostasis ( J:144744 )

• impaired insulin and glucagon response to challenge with arginine

• insulin tolerance test suggests a slight improvement in glucose disposal

abnormal insulin secretion ( J:144744 )

• in a 10 minute static test cultured cells fail to respond to elevated glucose levels which will cause a 2.3 fold increase in insulin secretion by control cells

increased circulating glucose level ( J:144744 )

• basal plasma glucose levels are significantly elevated at 12 weeks

impaired glucose tolerance ( J:144744 )

• delayed glucose clearance in an intravenous glucose tolerance test of 12 week old fasted mice but not 12 week old fed mice

• initial insulin response is severely blunted in both fasted and fed mice

endocrine/exocrine glands

abnormal pancreatic beta cell morphology ( J:144744 )

• significantly increased beta cell insulin content

increased pancreatic beta cell mass ( J:144744 )

abnormal insulin secretion ( J:144744 )

• in a 10 minute static test cultured cells fail to respond to elevated glucose levels which will cause a 2.3 fold increase in insulin secretion by control cells

adipose tissue

increased percent body fat/body weight ( J:144744 )

• significantly increase in overall body fat although body mass remains normal

growth/size/body

decreased lean body mass ( J:144744 )