Analysis Tools
digestive/alimentary system
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• after 6 months, acinar cells exhibit loss of cell height, enlargement of central lumen, and failure to stain uniformly for the acinar-specific marker amylase unlike wild-type cells
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• after 6 months, acinar cells exhibit increased proliferation compared to in wild-type cells
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endocrine/exocrine glands
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• after 6 months, acinar cells exhibit loss of cell height, enlargement of central lumen, and failure to stain uniformly for the acinar-specific marker amylase unlike wild-type cells
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• after 6 months, acinar cells exhibit increased proliferation compared to in wild-type cells
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• at 4 to 7 months, 24% of mice exhibit fibrotic inflammation in the pancreas unlike wild-type mice
• at 24 weeks, fibrosis in the form of collagen deposition and pancreatic stellate cell activation is evident unlike in wild-type mice
• at 1 year, 40% of mice exhibit pancreatic fibrosis
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• at 7 weeks of age, mice develop regions of progressive acinar cell damage with characteristics of necrosis unlike in wild-type mice
• however, duct and islet cells are not effected
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• pancreatic inflammatory infiltrate is composed of T cells, B cells, and macrophages
• mice older than 6 months exhibit chronic pancreatic inflammatory lesions
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• treatment with cerulein after 1 week produces an inflammatory response in the pancreas unlike in wild-type mice
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immune system
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• pancreatic inflammatory infiltrate is composed of T cells, B cells, and macrophages
• mice older than 6 months exhibit chronic pancreatic inflammatory lesions
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• treatment with cerulein after 1 week produces an inflammatory response in the pancreas unlike in wild-type mice
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