Analysis Tools
nervous system
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• kainate-treated mice exhibit decreased latency to seizure and increased seizure stage compared to similarly treated wild-type mice
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• at 10 months, neurons have abnormally ballooned structures unlike in wild-type mice
• the reticulum and lysosomes of neurons in the neocortex, thalamus, amygdala, pons, and spinal cord accumulate the mutant protein unlike in heterozygous mice or mice expressing the wild-type human protein
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behavior/neurological
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• kainate-treated mice exhibit decreased latency to seizure and increased seizure stage compared to similarly treated wild-type mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| familial encephalopathy with neuroserpin inclusion bodies | DOID:0050831 |
OMIM:604218 |
J:144649 | |
