Analysis Tools
hematopoietic system
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• lin - kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 20- to 40- fold more B cells than controls when cultured under condition supporting lymphopoiesis
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• lin- kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 10-fold lower percentages and numbers of myeloid lineage cells in vitro than controls
• however, normal number of myeloid cells are produced from myeloid progenitor cells
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immune system
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• lin - kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 20- to 40- fold more B cells than controls when cultured under condition supporting lymphopoiesis
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• lin- kit+ Sca-1+ progenitor cells isolated from the bone marrow of mice treated with tamoxifen produce 10-fold lower percentages and numbers of myeloid lineage cells in vitro than controls
• however, normal number of myeloid cells are produced from myeloid progenitor cells
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