Analysis Tools|
Allele Symbol Allele Name Allele ID |
Nrarptm1Vlcg targeted mutation 1, Velocigene MGI:3833551 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• retinal capillaries are less resistant to oxygen-induced vaso-obliteration compared with wild-type capillaries
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• retinal capillaries are less resistant to oxygen-induced vaso-obliteration compared with wild-type capillaries
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• vessel density is decreased compared to in wild-type retina
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• retinal vasculature is narrow at branch points, unstable and poorly lumenized with slender sprouts compared to in wild-type retina
• the continuous junctions that decorate the capillary plexus in the retina are fragmented compared to in wild-type retinas
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
• however, pericyte recruitment is normal
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• more vessel regression is observed in the retina than in wild-type mice
• constitutive activation of Ctnnb1 of inhibition of Notch signaling by DAPT treatment fails to rescue vessel regression
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
|
|
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• vessel density is decreased compared to in wild-type retina
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• retinal vasculature is narrow at branch points, unstable and poorly lumenized with slender sprouts compared to in wild-type retina
• the continuous junctions that decorate the capillary plexus in the retina are fragmented compared to in wild-type retinas
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
• however, pericyte recruitment is normal
|
|
• more vessel regression is observed in the retina than in wild-type mice
• constitutive activation of Ctnnb1 of inhibition of Notch signaling by DAPT treatment fails to rescue vessel regression
|
|
• proliferation of endothelial cells in the retina is decreased compared to in wild-type retina
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• vessel density is decreased compared to in wild-type retina
• retinal vasculature exhibits slender sprouts compared to in wild-type retina
|
|
• more vessel regression is observed in the retina than in wild-type mice
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
|
|
• at P7, radial expansion of the retinal vascular plexus from the optic nerve head to the periphery is impaired
• however, retinal vascular angiogenesis is partially resolved by P10, and only mild patterning defects are present at P14
• vessel density is decreased compared to in wild-type retina
• retinal vasculature exhibits slender sprouts compared to in wild-type retina
|
|
• more vessel regression is observed in the retina than in wild-type mice
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/19/2024 MGI 6.24 |
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