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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Pold1tm1.1Uchi
targeted mutation 1.1, Arikuni Uchimura
MGI:3833575
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Pold1tm1.1Uchi/Pold1tm1.1Uchi C57BL/6-Pold1tm1.1Uchi MGI:3833590
ht2
 		Pold1tm1Uchi/Pold1tm1.1Uchi C57BL/6-Pold1tm1Uchi/Pold1tm1.1Uchi MGI:3833591


Genotype
MGI:3833590
hm1
Allelic
Composition		 Pold1tm1.1Uchi/Pold1tm1.1Uchi
Genetic
Background		 C57BL/6-Pold1tm1.1Uchi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1.1Uchi mutation (4 available); any Pold1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144992 )
• appear otherwise to be viable and fertile
• prone to develop a swollen thymus and die between 3 and 8 months of age

embryo
embryo phenotype ( J:144992 )
N
• E12.5 embryos are morphologically like controls

immune system
enlarged thymus ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age

neoplasm
increased tumor incidence ( J:144992 )
• mice surviving beyond 12 months tend to develop nodules on their tails

hematopoietic system
enlarged thymus ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age

endocrine/exocrine glands
enlarged thymus ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age




Genotype
MGI:3833591
ht2
Allelic
Composition		 Pold1tm1Uchi/Pold1tm1.1Uchi
Genetic
Background		 C57BL/6-Pold1tm1Uchi/Pold1tm1.1Uchi
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pold1tm1.1Uchi mutation (4 available); any Pold1 mutation (62 available)
Pold1tm1Uchi mutation (1 available); any Pold1 mutation (62 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Tumors arise in Pold1tm1Uchi/Pold1tm1.1Uchi mice

mortality/aging
premature death ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age
• appear otherwise to be viable and fertile

embryo
embryo phenotype ( J:144992 )
N
• E12.5 embryos are morphologically like controls

immune system
enlarged thymus ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age

neoplasm
increased tumor incidence ( J:144992 )
• mice surviving beyond 12 months tend to develop nodules on their tails

hematopoietic system
enlarged thymus ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age

endocrine/exocrine glands
enlarged thymus ( J:144992 )
• prone to develop a swollen thymus and die between 3 and 8 months of age




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
08/02/2024
MGI 6.24 		The Jackson Laboratory