All Phenotypes Dab1<tm6Cpr> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Dab1^tm6Cpr
targeted mutation 6, Jonathan A Cooper
MGI:3833830

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dab1^tm6Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833855
ht2	Dab1^tm5Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833854
ht3	Dab1^tm1Cpr/Dab1^tm6Cpr	involves: 129S4/SvJaeSor * C57BL/6	MGI:3833856

Allelic Composition	Dab1^tm6Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal telencephalon development ( J:145031 )

abnormal cortical marginal zone morphology ( J:145031 )

• absent

abnormal subplate morphology ( J:145031 )

• poorly developed at E16.5

abnormal hippocampus morphology ( J:145031 )

• disorganized

abnormal cerebral cortex morphology ( J:145031 )

• disorganized

abnormal stratification in cerebral cortex ( J:145031 )

• disrupted order of neocortical layers

abnormal cerebellum morphology ( J:145031 )

ectopic Purkinje cell ( J:145031 )

• about 1/3 of cells are positioned normally above the internal granule layer, while others remain in or below the internal granule layer

small cerebellum ( J:145031 )

Allelic Composition	Dab1^tm5Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm5Cpr mutation (0 available); any Dab1 mutation (79 available)
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

nervous system phenotype ( J:145031 )

N	• mutant animals are viable with no obvious abnormalities • mutant animals have a well developed cortical marginal zone, normal hippocampus, and a cerebellum of normal size and foliation pattern

Allelic Composition	Dab1^tm1Cpr/Dab1^tm6Cpr
Genetic Background	involves: 129S4/SvJaeSor * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dab1^tm1Cpr mutation (1 available); any Dab1 mutation (79 available)
Dab1^tm6Cpr mutation (0 available); any Dab1 mutation (79 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal cortical marginal zone morphology ( J:145031 )

• absent

abnormal stratification in cerebral cortex ( J:145031 )

• disrupted order of neocortical layers

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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