Analysis Tools
homeostasis/metabolism
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• lipopolysaccharide induced initial elevation in nitrite/nitrate levels is similar to that of controls but drops back to normal more rapidly
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• response to non-lethal ip injection with E. coli lipopolysaccharide comparable to blood urea nitrogen response
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• levels peak 6 hours after non-lethal ip injection with E. coli lipopolysaccharide rather than continue to rise until 12 hours as occurs with controls
• levels lower than controls at 6, 12, and 24 hours after treatment
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• lipopolysaccharide induced hypothermia reaches its lowest level after 2 hours whereas the temperature drop continues to 6 hours in controls
• body temperature recovery beginning by 6 hours after treatment
• body temperature is comparable to experimental controls by 12 hours after treatment
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• elevated levels of Il12, Il5, and Il6 in the colon with sodium dextran sulfate induced colitis
(J:145685)
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• lipopolysaccharide induced response is less than in controls
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• with sodium dextran sulfate induced colitis
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• with sodium dextran sulfate induced colitis
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• elevated levels of Ccl2 and Ccl5 with sodium dextran sulfate induced colitis
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• lipopolysaccharide induced response is less than in controls
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renal/urinary system
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• less damage after non-lethal ip injection with E. coli lipopolysaccharide than occurs in controls
• less accumulation of red blood cells between tubules
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• less brush border damage than controls after non-lethal ip injection with E. coli lipopolysaccharide
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• increase in bladder permeability is less after transurethral administration of E. coli lipopolysaccharide than for controls
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• less elevation of urinary bladder weight (i.e. less bladder edema) and less leukocyte infiltration into the bladder (as measured by myeloperoxidase activity) than controls after transurethral administration of E. coli lipopolysaccharide
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immune system
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• increased susceptibility to colitis induced by delivery of sodium dextran sulfate in the drinking water
• weight loss and rectal bleeding
• increased colon damage relative to controls
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• leukocyte infiltration of the bladder after transurethral administration of E. coli lipopolysaccharide less than in controls as measured by myeloperoxidase activity
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• elevated levels of Il12, Il5, and Il6 in the colon with sodium dextran sulfate induced colitis
(J:145685)
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• lipopolysaccharide induced response is less than in controls
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• with sodium dextran sulfate induced colitis
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• with sodium dextran sulfate induced colitis
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• elevated levels of Ccl2 and Ccl5 with sodium dextran sulfate induced colitis
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• lipopolysaccharide induced response is less than in controls
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• less elevation of urinary bladder weight (i.e. less bladder edema) and less leukocyte infiltration into the bladder (as measured by myeloperoxidase activity) than controls after transurethral administration of E. coli lipopolysaccharide
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reproductive system
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• significantly reduced litter size
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digestive/alimentary system
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• increased susceptibility to colitis induced by delivery of sodium dextran sulfate in the drinking water
• weight loss and rectal bleeding
• increased colon damage relative to controls
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hematopoietic system
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• leukocyte infiltration of the bladder after transurethral administration of E. coli lipopolysaccharide less than in controls as measured by myeloperoxidase activity
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