Analysis Tools
growth/size/body
|
• reduced body weight compared to controls throughout life
|
|
• marked reduction in weight gain after birth
|
|
• when fed a high fat diet
|
muscle
|
• muscle triglyceride levels are decreased compared to controls when fed a high fat diet
• muscle triglyceride levels are similar to controls on a normal diet but
|
cellular
|
• enhanced glucose uptake in brown adipose tissue in vivo but not in isolated primary adipocytes from brown adipose tissue
|
behavior/neurological
|
• significant increase in food intake normalized to body weight
|
|
• slight increase in locomotor activity that is more apparent in the dark phase
|
adipose tissue
|
• in mice fed a high fat diet but not in mice fed a normal diet
|
|
• marked reduction in cell size in both white and brown adipose tissue
|
|
• reduction in the mass of epididymal white adipose tissue on a normal or high fat diet compared to diet matched controls
|
|
• enhanced glucose uptake in brown adipose tissue in vivo but not in isolated primary adipocytes from brown adipose tissue
|
homeostasis/metabolism
| N |
• despite the increase in metabolic rate, no difference in body temperature compared to controls is detected and no defect in adaptive thermogenesis is seen
• unlike metabolic rate, respiratory quotient in mice fed a high fat diet is similar to diet matched controls
|
|
• when fed a high fat diet
|
|
• on a standard diet
|
|
• on a standard diet
|
|
• on a standard or high fat diet
|
|
• on a standard diet
|
|
• on a standard or high fat diet
|
|
• on a standard diet
|
|
• on a standard diet
|
|
• reduction in liver triglyceride levels on a normal or high fat diet compared to diet matched controls
|
|
• muscle triglyceride levels are decreased compared to controls when fed a high fat diet
• muscle triglyceride levels are similar to controls on a normal diet but
|
|
• enhanced metabolic rate in both dark and light phases
• metabolic rate is also increased when fed a high fat diet compared to diet matched controls
|
liver/biliary system
|
• reduction in liver triglyceride levels on a normal or high fat diet compared to diet matched controls
|
|
• resistance to high fat diet induce hepatic steatosis
|
digestive/alimentary system
| N |
• assays indicate nutrient absorption is not significantly different from controls
|
integument
