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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp1r15btm1Dron
targeted mutation 1, David Ron
MGI:3833920
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp1r15btm1Dron/Ppp1r15btm1Dron involves: 129P2/OlaHsd MGI:3833922
cx2
 		Eif2s1tm1Rjk/Eif2s1+
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd MGI:3833923
cx3
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd MGI:3833924
cx4
 		Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833925
cx5
 		Ppp1r15atm1Dron/Ppp1r15a+
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833926
cx6
 		Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15b+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833927
cx7
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833928


Genotype
MGI:3833922
hm1
Allelic
Composition		 Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Stunted growth of Ppp1r15btm1Dron/Ppp1r15btm1Dron mice

mortality/aging
neonatal lethality, complete penetrance ( J:144954 )
• mice die within the first day of life

hematopoietic system
abnormal erythrocyte morphology ( J:144954 )
• red blood cell size and shape are abnormal
echinocytosis ( J:144954 )
• at E18.5

growth/size/body
decreased birth body size ( J:144954 )
• pups are half the size of wild-type mice at birth

liver/biliary system
abnormal liver morphology ( J:144954 )
• liver morphology is consistent with compensatory proliferation of blood precursors

behavior/neurological
abnormal suckling behavior ( J:144954 )
• mice fail to suckle

integument
pallor ( J:144954 )
• at birth




Genotype
MGI:3833923
cx2
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1+
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased fetal weight ( J:144954 )
• at E18.5

hematopoietic system




Genotype
MGI:3833924
cx3
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:144954 )
• mice die after birth due to hypoglycemia

hematopoietic system
decreased erythrocyte cell number ( J:144954 )
• at E18.5, red blood cell counts are less than in wild-type mice but greater than in Ppp1r15btm1Dron homozygotes

growth/size/body
decreased fetal weight ( J:144954 )
• at E18.5, weight is less than in wild-type mice but greater than in Ppp1r15btm1Dron homozygotes

homeostasis/metabolism




Genotype
MGI:3833925
cx4
Allelic
Composition		 Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ppp1r15atm1Dron/Ppp1r15atm1Dron Ppp1r15btm1Dron/Ppp1r15btm1Dron embryos fail to develop past the preimplantation period

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:144954 )
• embryos do not develop beyond pre-implantation stages




Genotype
MGI:3833926
cx5
Allelic
Composition		 Ppp1r15atm1Dron/Ppp1r15a+
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3833927
cx6
Allelic
Composition		 Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15b+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144954 )
N
• mice survive into adulthood




Genotype
MGI:3833928
cx7
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (14 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144954 )
N
• mice survive until E17.5

growth/size/body
growth/size/body region phenotype ( J:144954 )
N
• unlike Ppp1r15btm1Dron homozygotes, mice are of normal size at E17.5




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/17/2024
MGI 6.24 		The Jackson Laboratory