Phenotypes associated with this allele

• Allele Symbol: Sgpl1^{tm1(SGPL1)Lex}
• Allele Name: targeted mutation 1, Lexicon Genetics
• Allele ID: MGI:3833933
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Sgpl1^tm1(SGPL1)Lex/Sgpl1^tm1(SGPL1)Lex	involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J	MGI:3833998
ht2	Sgpl1^Gt(OST58278)Lex/Sgpl1^tm1(SGPL1)Lex	involves: 129S5/SvEvBrd * C57BL/6J	MGI:3833999

Genotype
MGI:3833998

hm1

• Allelic Composition: Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex}
• Genetic Background: involves: 129S4/SvJae * 129S5/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Thymus abnormalities in Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}, Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} and Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{Gt(OST58278)Lex} mice

immune system

increased single-positive T cell number ( J:145159 )

• in the thymus

decreased lymphocyte cell number ( J:145159 )

• peripheral lymphocytes are decreased compared to in wild-type mice

decreased B cell number ( J:145159 )

• by 40% in the peripheral blood

decreased T cell number ( J:145159 )

• by 60% in the peripheral blood and thymus but not secondary lymphoid organs

decreased CD4-positive, alpha-beta T cell number ( J:145159 )

• in the blood

decreased CD8-positive, alpha-beta T cell number ( J:145159 )

• in the blood

abnormal immune system organ morphology ( J:145159 )

• lesions are observed in lymphoid tissues due to the retention of mature lymphocytes in the thymus and secondary lymphoid organs unlike in wild-type mice

• however, lesions are not observed in any other organ, and splenic white pulp, including periarteriolar lymphoid sheaths and follicles, is normal

abnormal thymus lobule morphology ( J:145159 )

• the number of lymphocytes in the thymic cortex is minimally decreased while the number of lymphocytes in the medulla is minimally increased compared to in wild-type mice

abnormal lymph node morphology ( J:145159 )

• mesenteric and peripheral lymph nodes exhibit expansion of the paracortical areas by sequestered lymphocytes unlike in wild-type mice

renal/urinary system

abnormal renal/urinary system morphology ( J:145159 )

• one of six aged mice exhibit minimal vacuolization of a few superficial urothelial cells unlike in wild-type mice

hematopoietic system

abnormal thymus lobule morphology ( J:145159 )

• the number of lymphocytes in the thymic cortex is minimally decreased while the number of lymphocytes in the medulla is minimally increased compared to in wild-type mice

increased single-positive T cell number ( J:145159 )

• in the thymus

decreased lymphocyte cell number ( J:145159 )

• peripheral lymphocytes are decreased compared to in wild-type mice

decreased B cell number ( J:145159 )

• by 40% in the peripheral blood

decreased T cell number ( J:145159 )

• by 60% in the peripheral blood and thymus but not secondary lymphoid organs

decreased CD4-positive, alpha-beta T cell number ( J:145159 )

• in the blood

decreased CD8-positive, alpha-beta T cell number ( J:145159 )

• in the blood

endocrine/exocrine glands

abnormal thymus lobule morphology ( J:145159 )

• the number of lymphocytes in the thymic cortex is minimally decreased while the number of lymphocytes in the medulla is minimally increased compared to in wild-type mice

Genotype
MGI:3833999

ht2

• Allelic Composition: Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{tm1(SGPL1)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6J

Thymus abnormalities in Sgpl1^{Gt(OST58278)Lex}/Sgpl1^{Gt(OST58278)Lex}, Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{tm1(SGPL1)Lex} and Sgpl1^{tm1(SGPL1)Lex}/Sgpl1^{Gt(OST58278)Lex} mice

immune system

decreased T cell number ( J:145159 )

• mice have fewer circulating T cells than in Sgpl1^{tm1(SGPL1)Lex} homozygotes

abnormal osteoclast morphology ( J:145159 )

• a small number of distended osteoclasts are present at the growth plate

• however, mice exhibit normal trabecular bone in the meptaphysis and diaphysis of the long bones

abnormal immune system organ morphology ( J:145159 )

• mice exhibit the same defects in lymphoid tissue morphology as in Sgpl1^{tm1(SGPL1)Lex} homozygotes

• however, mice do not exhibit defects in non-lymphoid tissues

thymus cortex hypoplasia ( J:145159 )

• the number of lymphocytes in the thymic cortex is mildly decreased compared to in wild-type mice

thymus medulla hyperplasia ( J:145159 )

• the number of lymphocytes in the medulla is mildly increased compared to in wild-type mice

renal/urinary system

abnormal urinary bladder urothelium morphology ( J:145159 )

• mice exhibit multifocal minimal vacuolization and degeneration of the urinary bladder urothelium unlike in wild-type mice

skeleton

abnormal osteoclast morphology ( J:145159 )

• a small number of distended osteoclasts are present at the growth plate

• however, mice exhibit normal trabecular bone in the meptaphysis and diaphysis of the long bones

cardiovascular system

cardiovascular system phenotype ( J:145159 )

N • heart morphology is normal

respiratory system

respiratory system phenotype ( J:145159 )

N • lung morphology is normal

hematopoietic system

thymus cortex hypoplasia ( J:145159 )

• the number of lymphocytes in the thymic cortex is mildly decreased compared to in wild-type mice

thymus medulla hyperplasia ( J:145159 )

• the number of lymphocytes in the medulla is mildly increased compared to in wild-type mice

decreased T cell number ( J:145159 )

• mice have fewer circulating T cells than in Sgpl1^{tm1(SGPL1)Lex} homozygotes

abnormal osteoclast morphology ( J:145159 )

• a small number of distended osteoclasts are present at the growth plate

• however, mice exhibit normal trabecular bone in the meptaphysis and diaphysis of the long bones

endocrine/exocrine glands

thymus cortex hypoplasia ( J:145159 )

• the number of lymphocytes in the thymic cortex is mildly decreased compared to in wild-type mice

thymus medulla hyperplasia ( J:145159 )

• the number of lymphocytes in the medulla is mildly increased compared to in wild-type mice