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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gng7tm1(cre)Mmsh
targeted mutation 1, Masayoshi Mishina
MGI:3833955
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Drd1tm1.1Mmsh/Drd1tm1.1Mmsh
Gng7tm1(cre)Mmsh/? 		involves: C57BL/6N MGI:5698151
cn2
 		Drd2tm1.1Mmsh/Drd2tm1.1Mmsh
Gng7tm1(cre)Mmsh/? 		involves: C57BL/6N MGI:5698152


Genotype
MGI:5698151
cn1
Allelic
Composition		 Drd1tm1.1Mmsh/Drd1tm1.1Mmsh
Gng7tm1(cre)Mmsh/?
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd1tm1.1Mmsh mutation (1 available); any Drd1 mutation (70 available)
Gng7tm1(cre)Mmsh mutation (0 available); any Gng7 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:210178 )
N
• normal nociceptive response to electric shock
impaired cued conditioning behavior ( J:210178 )
• smaller freezing response 1 day after foot shock conditioning than seen in controls
• very little freezing response 10 minutes after a single shock
• five consecutive shocks on the first day increases freezing response but response is still less than controls




Genotype
MGI:5698152
cn2
Allelic
Composition		 Drd2tm1.1Mmsh/Drd2tm1.1Mmsh
Gng7tm1(cre)Mmsh/?
Genetic
Background		 involves: C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Drd2tm1.1Mmsh mutation (1 available); any Drd2 mutation (70 available)
Gng7tm1(cre)Mmsh mutation (0 available); any Gng7 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
behavior/neurological phenotype ( J:210178 )
N
• normal nociceptive response to electric shock
• freezing response comparable to that seen in controls 1 day after foot shock conditioning




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory