Analysis Tools
nervous system
|
• at P0, the deep cutaneous plexus is connected to the epidermal plexus by several horizontal plexuses connected by a random and interlacing network of fibers unlike in wild-type mice
• however, mice exhibit normal innervation of the skin at E17.5, whisker pad innervation, and sympathetic fiber innervation
• terminal branches to the epidermis are numerous with nerve fiber density twice as much as in wild-type mice
• at P2, denser and more disorganized innervation of the dorsal skin persists and becomes more obvious, the dermal plexus is located deeper than normal with radial fibers thicker and more frequently branched than in wild-type mice, and the subepidermal plexus fails to form with free nerve endings in the basal layer of the epidermis more profuse than in wild-type skin
• at P5, the pattern of normal skin innervation is absent with a thick deep cutaneous plexus that forms several defasciculated bundles of fibers and the replacement of obliquely parallel radial bundles with an extensive network of terminal spanning the entire region between the deep cutaneous and subepidermal plexus unlike in wild-type skin
• at P7, epidermal free nerve endings are increased by 60% compared to in wild-type skin, and the isthmus region contains an extensive bundle of nerve fibers that branch in different directions without forming circular plexuses or elaborating any vertical spikes unlike in wild-type skin
• at P18, lanceolate endings exhibit poorly developed circular plexus and rudimentary palisades with few and short vertical spikes unlike in wild-type skin
|
|
• dorsal root ganglion nerves exhibit extensive branching in culture compared to wild-type neurons with a 60% increase in branch points
• however, the number of nerve cells in the dorsal root ganglion is normal
|
integument
|
• hair follicles are disorganized at P7 to P8
|
