Phenotypes associated with this allele

• Allele Symbol: Tg(Myh6-Pln)416Egk
• Allele Name: transgene insertion 416, Evangelia G Kranias
• Allele ID: MGI:3834110
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
tg1	Tg(Myh6-Pln)416Egk/?	FVB/N-Tg(Myh6-Pln)416Egk	MGI:5052047

Genotype
MGI:5052047

tg1

• Allelic Composition: Tg(Myh6-Pln)416Egk/?
• Genetic Background: FVB/N-Tg(Myh6-Pln)416Egk

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal cardiac muscle contractility ( J:135899 )

• left ventricular cardiomyocytes exhibit diminished shortening fraction (37% decrease), decreased rates of shortening (36%) and re-lengthening (45%)

• although basal rates of shortening and re-lengthening are decreased, response to the beta adrenergic agonist, isoproterenol, is similar to control

abnormal myocardial fiber physiology ( J:135899 )

• calcium uptake rates into the sarcoplasmic reticulum are lower than controls, however there is no change in maximum velocity

• amplitude of the systolic Ca²⁺ transient is lower and time for 80% decay is prolonged

muscle

abnormal cardiac muscle contractility ( J:135899 )

• left ventricular cardiomyocytes exhibit diminished shortening fraction (37% decrease), decreased rates of shortening (36%) and re-lengthening (45%)

• although basal rates of shortening and re-lengthening are decreased, response to the beta adrenergic agonist, isoproterenol, is similar to control