Phenotypes associated with this allele

• Allele Symbol: Gli2^tm1Blnw
• Allele Name: targeted mutation 1, Baolin Wang
• Allele ID: MGI:3834146
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli2^tm1Blnw/Gli2^tm1Blnw	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3834147
cx2	Gli2^tm1Blnw/Gli2^tm1Blnw Shh^tm1Chg/Shh^tm1Chg	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3834148

Genotype
MGI:3834147

hm1

• Allelic Composition: Gli2^tm1Blnw/Gli2^tm1Blnw
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality, complete penetrance ( J:145182 )

• homozygotes die in utero

nervous system

abnormal neural tube morphology ( J:145182 )

• slightly enlarged

abnormal neural tube closure ( J:145182 )

• defective

exencephaly ( J:145182 )

• midbrain exencephaly

craniofacial

abnormal maxillary dental arch morphology ( J:145182 )

• enlarged maxillary arch

abnormal maxillary frontal process morphology ( J:145182 )

• broadened nasal processes

limbs/digits/tail

polydactyly ( J:145182 )

• extra digits on the anterior of each limb

skeleton

abnormal maxillary dental arch morphology ( J:145182 )

• enlarged maxillary arch

abnormal maxillary frontal process morphology ( J:145182 )

• broadened nasal processes

embryo

abnormal neural tube morphology ( J:145182 )

• slightly enlarged

abnormal neural tube closure ( J:145182 )

• defective

Genotype
MGI:3834148

cx2

• Allelic Composition: Gli2^tm1Blnw/Gli2^tm1Blnw; Shh^tm1Chg/Shh^tm1Chg
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

cellular

cellular phenotype ( J:145182 )

N • normal levels of apoptotic cells in the neural tube

nervous system

nervous system phenotype ( J:145182 )

N • normal sized neural tube