All Phenotypes Eaf2<tm1Zhow> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eaf2^tm1Zhow/Eaf2^tm1Zhow	involves: 129P2/OlaHsd	MGI:6694951
hm2	Eaf2^tm1Zhow/Eaf2^tm1Zhow	involves: 129P2/OlaHsd * C57BL/6J	MGI:3834182
ht3	Eaf2^tm1Zhow/Eaf2⁺	involves: 129P2/OlaHsd * C57BL/6J	MGI:3834183
cn4	Eaf1^tm1.1Zhow/Eaf1^tm1.1Zhow Eaf2^tm1Zhow/Eaf2^tm1Zhow Tg(Pbsn-cre)4Prb/0	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * DBA/2	MGI:6694954

Allelic Composition	Eaf2^tm1Zhow/Eaf2^tm1Zhow
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eaf2^tm1Zhow mutation (0 available); any Eaf2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:288972 )

• mouse prostatic intraepithelial neoplasia (mPIN) lesions

abnormal prostate gland physiology ( J:288972 )

• increased epithelial cell proliferation in ventral prostate

prostate gland inflammation ( J:288972 )

• stroma inflammation

• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

immune system

prostate gland inflammation ( J:288972 )

• stroma inflammation

• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:288972 )

• mouse prostatic intraepithelial neoplasia (mPIN) lesions

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:288972 )

• mouse prostatic intraepithelial neoplasia (mPIN) lesions

abnormal prostate gland physiology ( J:288972 )

• increased epithelial cell proliferation in ventral prostate

prostate gland inflammation ( J:288972 )

• stroma inflammation

• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:145228 )

• mice begin to die at 4 months of age with 32% mortality by 16 months

• however, beyond 16 months sudden death is rate

neoplasm

increased tumor incidence ( J:145228 )

• in 82% of mice compared to 5% of wild-type mice

increased prostate intraepithelial neoplasia incidence ( J:145228 )

• 8 of 15 mice exhibit prostate intraepithelial neoplasia that does not develop into invasive prostate cancer

increased skin tumor incidence ( J:145228 )

• in 5% of mice

increased hepatocellular carcinoma incidence ( J:145228 )

• in 32% of mice

increased B cell derived lymphoma incidence ( J:145228 )

• 45% of mice develop lymphomas that are found in the spleen, liver, lung, kidney, intestine, abdomen, and skin

increased lung adenocarcinoma incidence ( J:145228 )

• in 53% of mice

reproductive system

abnormal prostate gland morphology ( J:145228 )

• at 6 months, 11 of 13 mice exhibit prostate abnormalities including a more opaque-whitish appearance compared to in wild-type mice

abnormal prostate gland epithelium morphology ( J:145228 )

• the ventral, lateral and anterior, but not dorsal, prostate display hyperplasia and hypertrophy with some severe dysplasia

• epithelium cells exhibit a 4.5- to 5.7-fold increase in proliferation compared to in wild-type mice

• epithelial cell size increases 33% compared to in wild-type mice

increased prostate gland weight ( J:145228 )

• at 6 months, ventral and dorsal prostate lobes exhibit a 20% to 30% increase in weight

increased prostate intraepithelial neoplasia incidence ( J:145228 )

• 8 of 15 mice exhibit prostate intraepithelial neoplasia that does not develop into invasive prostate cancer

cardiovascular system

abnormal heart morphology ( J:145228 )

• at 6 to 12 months, cardiac cell density is decreased 20% compared to in wild-type mice

enlarged heart ( J:145228 )

• at 6 to 12 months, 39% of mice exhibit enlarged hearts

endocrine/exocrine glands

abnormal prostate gland morphology ( J:145228 )

• at 6 months, 11 of 13 mice exhibit prostate abnormalities including a more opaque-whitish appearance compared to in wild-type mice

abnormal prostate gland epithelium morphology ( J:145228 )

• the ventral, lateral and anterior, but not dorsal, prostate display hyperplasia and hypertrophy with some severe dysplasia

• epithelium cells exhibit a 4.5- to 5.7-fold increase in proliferation compared to in wild-type mice

• epithelial cell size increases 33% compared to in wild-type mice

increased prostate gland weight ( J:145228 )

• at 6 months, ventral and dorsal prostate lobes exhibit a 20% to 30% increase in weight

increased prostate intraepithelial neoplasia incidence ( J:145228 )

• 8 of 15 mice exhibit prostate intraepithelial neoplasia that does not develop into invasive prostate cancer

integument

increased skin tumor incidence ( J:145228 )

• in 5% of mice

growth/size/body

enlarged heart ( J:145228 )

• at 6 to 12 months, 39% of mice exhibit enlarged hearts

respiratory system

increased lung adenocarcinoma incidence ( J:145228 )

• in 53% of mice

liver/biliary system

increased hepatocellular carcinoma incidence ( J:145228 )

• in 32% of mice

Allelic Composition	Eaf2^tm1Zhow/Eaf2⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eaf2^tm1Zhow mutation (0 available); any Eaf2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:145228 )

• in 44% of mice compared to 5% of wild-type mice

increased lymphoma incidence ( J:145228 )

• in 22% of mice

increased lung adenocarcinoma incidence ( J:145228 )

• in 22% of mice

respiratory system

increased lung adenocarcinoma incidence ( J:145228 )

• in 22% of mice

Allelic Composition	Eaf1^tm1.1Zhow/Eaf1^tm1.1Zhow Eaf2^tm1Zhow/Eaf2^tm1Zhow Tg(Pbsn-cre)4Prb/0
Genetic Background	involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J * DBA/2

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eaf1^tm1.1Zhow mutation (0 available); any Eaf1 mutation (17 available)
Eaf2^tm1Zhow mutation (0 available); any Eaf2 mutation (19 available)
Tg(Pbsn-cre)4Prb mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

increased prostate intraepithelial neoplasia incidence ( J:288972 )

• mouse prostatic intraepithelial neoplasia (mPIN) lesions

abnormal prostate gland physiology ( J:288972 )

• increased epithelial cell proliferation in ventral prostate

prostate gland inflammation ( J:288972 )

• stroma inflammation

• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

immune system

prostate gland inflammation ( J:288972 )

• stroma inflammation

• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

neoplasm

increased prostate intraepithelial neoplasia incidence ( J:288972 )

• mouse prostatic intraepithelial neoplasia (mPIN) lesions

reproductive system

increased prostate intraepithelial neoplasia incidence ( J:288972 )

• mouse prostatic intraepithelial neoplasia (mPIN) lesions

abnormal prostate gland physiology ( J:288972 )

• increased epithelial cell proliferation in ventral prostate

prostate gland inflammation ( J:288972 )

• stroma inflammation

• increased CD3+ T cell and CD19+ B cell infiltration of ventral prostate

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