Phenotypes associated with this allele

• Allele Symbol: Mbl1^tm1Rala
• Allele Name: targeted mutation 1, Rachel A Lawrence
• Allele ID: MGI:3834180
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mbl1^tm1Rala/Mbl1^tm1Rala	involves: 129X1/SvJ * C57BL/6J	MGI:3834184

Genotype
MGI:3834184

hm1

• Allelic Composition: Mbl1^tm1Rala/Mbl1^tm1Rala
• Genetic Background: involves: 129X1/SvJ * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal immunoglobulin level ( J:145279 )

increased IgG1 level ( J:145279 )

• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi

increased IgG2a level ( J:145279 )

• significantly elevated levels of specific antibody relative to controls at days 15 and 22 after infection with Brugia malayi

decreased IgG2b level ( J:145279 )

• significantly reduced response to immunization with OVA

increased IgG3 level ( J:145279 )

• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi

decreased IgM level ( J:145279 )

• levels of specific antibody relative to controls at day 15 after infection with Brugia malayi are very low

• response to challenge with OVA is also very low

increased susceptibility to parasitic infection ( J:145279 )

• Brugia malayi infections reach significantly higher levels by 7 days after infection than controls

• significant parasite load at 28 days after infection whereas control mice have completely cleared their infections

hematopoietic system

abnormal immunoglobulin level ( J:145279 )

increased IgG1 level ( J:145279 )

• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi

increased IgG2a level ( J:145279 )

• significantly elevated levels of specific antibody relative to controls at days 15 and 22 after infection with Brugia malayi

decreased IgG2b level ( J:145279 )

• significantly reduced response to immunization with OVA

increased IgG3 level ( J:145279 )

• significantly elevated levels of specific antibody relative to controls at day 15 after infection with Brugia malayi

decreased IgM level ( J:145279 )

• levels of specific antibody relative to controls at day 15 after infection with Brugia malayi are very low

• response to challenge with OVA is also very low