Phenotypes associated with this allele

• Allele Symbol: Lyz2^{tm1(HBEGF)Mtka}
• Allele Name: targeted mutation 1, Masato Tanaka
• Allele ID: MGI:3834185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Lyz2^tm1(HBEGF)Mtka/Lyz2^+	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3834193

Genotype
MGI:3834193

ht1

• Allelic Composition: Lyz2^{tm1(HBEGF)Mtka}/Lyz2⁺
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:145285 )

• treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion results in death within 96 hours unlike wild-type mice that survive at this dose

• 50% of mice die within a week of treatment with 10ug/kg DT

respiratory system

lung hemorrhage ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion

abnormal alveolar macrophage morphology ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, alveolar macrophages exhibit increased rates of apoptosis compared to in similarly treated wild-type mice

abnormal lung interstitium morphology ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, red blood cells expand in the interstitial mesenchyme indicating severe congestion in the lungs unlike in similarly treated wild-type mice

• congestion is less severe in irradiated mice transplanted with wild-type bone marrow and treated with DT compared to similarly treated mice transplanted with bone marrow from Lyz2^tm1(DTR)Mtka heterozygotes

abnormal pulmonary alveolus morphology ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, alveolar walls become thick and the alveolar spaces are diminished due to apoptosis of epitherlial cells and alveolar macrophages unlike in similarly treated wild-type mice

absent type II pneumocytes ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, alveolar epithelial type II cells are hardly detected compared to in similarly treated wild-type mice

• irradiated mice transplanted with wild-type bone marrow and treated with diphtheria toxin (DT) exhibit loss of type II cells without depletion of alveolar macrophages

respiratory failure ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, mice exhibit respiratory failure unlike similarly treated wild-type mice

• irradiated mice transplanted with wild-type bone marrow and treated with diphtheria toxin (DT) exhibit respiratory failure without depletion of alveolar macrophages

abnormal surfactant secretion ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, mice exhibit reduced production of surfactant proteins (A and B) compared to in similarly treated wild-type mice

immune system

abnormal alveolar macrophage morphology ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, alveolar macrophages exhibit increased rates of apoptosis compared to in similarly treated wild-type mice

homeostasis/metabolism

increased circulating lactate dehydrogenase level ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, serum lactose dehydrogenase levels are increased greater than 7-fold compared to in similarly treated wild-type mice

cardiovascular system

lung hemorrhage ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion

behavior/neurological

hunched posture ( J:145285 )

• within 96 hours of treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion

decreased locomotor activity ( J:145285 )

• within 96 hours of treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion

hematopoietic system

abnormal alveolar macrophage morphology ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, alveolar macrophages exhibit increased rates of apoptosis compared to in similarly treated wild-type mice

liver/biliary system

abnormal liver morphology ( J:145285 )

• following treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion, the liver exhibits slight congestions unlike in similarly treated wild-type mice

integument

ruffled hair ( J:145285 )

• within 96 hours of treatment with 40 ug/kg diphtheria toxin (DT) to induce macrophage depletion