All Phenotypes Kif22<tm1.1Tya> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kif22^tm1.1Tya
targeted mutation 1.1, Tadashi Yamamoto
MGI:3834595

Summary

2 genotypes

Allelic Composition	Kif22^tm1.1Tya/Kif22^tm1.1Tya
Genetic Background	B6.129P2(Cg)-Kif22^tm1.1Tya

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif22^tm1.1Tya mutation (0 available); any Kif22 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:145315 )

• 50% of expected mice die prior to 3 weeks of age

Allelic Composition	Kif22^tm1.1Tya/Kif22^tm1.1Tya
Genetic Background	involves: 129P2/OlaHsd * C57BL/6J * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kif22^tm1.1Tya mutation (0 available); any Kif22 mutation (34 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• 50% fewer than expected blastocysts are recovered at E3.5

• however, the number of 2 to 8 cell staged mice is normal

embryo

abnormal embryo development ( J:145315 )

• first and second polar bodies are retained within fertilized oocyte and results in multi-pronuclei at the 1-cell stage

• anaphase chromosome compaction results in the formation of multinucleated cells during oocyte meiosis II and early embryogenesis

cellular

abnormal chromosome morphology ( J:145315 )

• anaphase chromosome compaction results in the formation of multinucleated cells during oocyte meiosis II and early embryogenesis

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