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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Lpptm1Wjmv
targeted mutation 1, Wim JM Van de Ven
MGI:3834596
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Lpptm1Wjmv/Lpptm1Wjmv B6.129P2-Lpptm1Wjmv MGI:3834600
hm2
Lpptm1Wjmv/Lpptm1Wjmv involves: 129P2/OlaHsd * Swiss MGI:3834599


Genotype
MGI:3834600
hm1
Allelic
Composition
Lpptm1Wjmv/Lpptm1Wjmv
Genetic
Background
B6.129P2-Lpptm1Wjmv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpptm1Wjmv mutation (0 available); any Lpp mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• Background Sensitivity: slight deficiency of homozygotes at birth, particularly of females (17% vs 25%)
• no additional lethality after birth

reproductive system
N
• male reproductive system and fertility are normal
• crosses of homozygotes result in 46% fewer offspring
• high levels of embryo death and resorption or necrosis observed at various time points from E11.5 to E15.5
• survival of pups after birth reduced to about 50%

homeostasis/metabolism
• MEFs show a 50% reduction of migration into wounds 24 hours after injury

cellular
• MEFs die faster than normal




Genotype
MGI:3834599
hm2
Allelic
Composition
Lpptm1Wjmv/Lpptm1Wjmv
Genetic
Background
involves: 129P2/OlaHsd * Swiss
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lpptm1Wjmv mutation (0 available); any Lpp mutation (91 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• Background Sensitivity: mice born at a normal Mendelian ratio





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last database update
12/10/2024
MGI 6.24
The Jackson Laboratory