Phenotypes associated with this allele

• Allele Symbol: Crtam^tm1Achn
• Allele Name: targeted mutation 1, Andrew C Chan
• Allele ID: MGI:3834613
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crtam^tm1Achn/Crtam^tm1Achn	involves: 129 * C57BL/6	MGI:3834614

Genotype
MGI:3834614

hm1

• Allelic Composition: Crtam^tm1Achn/Crtam^tm1Achn
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased CD4-positive, alpha-beta T cell number ( J:145314 )

• CD4⁺ T cell numbers increase with age so that by 9 months the number is more than two-thirds higher than in wild-type controls in both blood and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:145314 )

• CD8⁺ T cell numbers increase with age so that by 9 months they are more than two-thirds higher than in wild-type controls in both blood and lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:145314 )

• Th17 T cells produce less IL-17 and IL-22 than controls when stimulated

abnormal T-helper 1 physiology ( J:145314 )

• Th1 T cells produce less IFN-gamma than controls when activated

abnormal T cell activation ( J:145314 )

• 14 hours after activation, T cells fail to efficiently polarize Talin, CD44, and CD3 in the manner that wild-type T cells do

increased T cell proliferation ( J:145314 )

• both CD4⁺ and CD8⁺ T cells proliferate at a faster rate in vitro and in vivo

decreased interferon-gamma secretion ( J:145314 )

• there is a 5-fold decrease in IFN-gamma production by Th1 differentiated T cells with both primary and secondary TCR stimulations

• nave and memory/effector CD8⁺ T cells also produce less IFN-gamma when stimulated

abnormal interleukin secretion ( J:145314 )

• Th17 differentiated T cells produce less IL-22 than controls

decreased interleukin-17 secretion ( J:145314 )

• Th17 differentiated T cells produce less IL-17 than controls

increased susceptibility to bacterial infection ( J:145314 )

• there is a one log unit increase in bacterial burden in the colon 7 days after Citrobacter rodentium infection

• there is two log unit increase in bacterial burden in the spleen 7 and 14 days after C. rodentium infection

hematopoietic system

increased CD4-positive, alpha-beta T cell number ( J:145314 )

• CD4⁺ T cell numbers increase with age so that by 9 months the number is more than two-thirds higher than in wild-type controls in both blood and lymph nodes

increased CD8-positive, alpha-beta T cell number ( J:145314 )

• CD8⁺ T cell numbers increase with age so that by 9 months they are more than two-thirds higher than in wild-type controls in both blood and lymph nodes

abnormal CD4-positive, alpha-beta T cell physiology ( J:145314 )

• Th17 T cells produce less IL-17 and IL-22 than controls when stimulated

abnormal T-helper 1 physiology ( J:145314 )

• Th1 T cells produce less IFN-gamma than controls when activated

abnormal T cell activation ( J:145314 )

• 14 hours after activation, T cells fail to efficiently polarize Talin, CD44, and CD3 in the manner that wild-type T cells do

increased T cell proliferation ( J:145314 )

• both CD4⁺ and CD8⁺ T cells proliferate at a faster rate in vitro and in vivo

cellular

increased T cell proliferation ( J:145314 )

• both CD4⁺ and CD8⁺ T cells proliferate at a faster rate in vitro and in vivo