Phenotypes associated with this allele

• Allele Symbol: Cngb1^tm1Hazh
• Allele Name: targeted mutation 1, Haiqing Zhao
• Allele ID: MGI:3834618
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cngb1^tm1Hazh/Cngb1^tm1Hazh	involves: 129S6/SvEvTac * BALB/cJ * C57BL/6	MGI:3834625

Genotype
MGI:3834625

hm1

• Allelic Composition: Cngb1^tm1Hazh/Cngb1^tm1Hazh
• Genetic Background: involves: 129S6/SvEvTac * BALB/cJ * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal action potential ( J:145296 )

• the ability of olfactory sensory neurons to fire second action potential following second exposure to stimulant during a short recovery period is impaired compared to in wild-type mice

abnormal single cell response ( J:145296 )

• in single olfactory sensory neurons, the current decline is longer than in wild-type mice

abnormal neuron physiology ( J:145296 )

• olfactory sensory neurons exhibit only a slow desensitization by calcium ions and calmodulin with kinetics around 100-fold slower than the fast desensitization observed in wild-type cells

• olfactory sensory neurons exhibit slower than normal odorant response termination

• recovery of local field potentials in olfactory bulb neurons is slower than in wild-type cells in a paired-pulse paradigm

• olfactory sensory neurons exhibit delayed time to peak and reduced adaptation during sustained stimulation compared to in wild-type cells

• however, olfactory sensory neurons exhibit normal initial response to odorant stimulation and oscillatory response pattern during prolonged odor stimulation

taste/olfaction

taste/olfaction phenotype ( J:145296 )

N • mice exhibit normal sensitivity to odorant stimulation, normal adaptation to repeated odorant exposure