All Phenotypes Tcra<Ln3Jae> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tcra^Ln3Jae/Tcra⁺	B6.Cg-Tcra^Ln3Jae	MGI:3834658
cx2	Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺	B6.Cg-Tcrb^Ln3Jae Tcra^Ln3Jae	MGI:3834654
cx3	Rag2^tm1Fwa/Rag2^tm1Fwa Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺	involves: 129S/SvEv * 129S4/SvJae * C57BL/6	MGI:3834655

Allelic Composition	Tcra^Ln3Jae/Tcra⁺
Genetic Background	B6.Cg-Tcra^Ln3Jae

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (101 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by more than 5-fold

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is found abundantly in the spleen making up 31% of the splenocyte population

decreased double-positive T cell number ( J:143006 )

• there is about a 2-fold reduction in the percentage of double-positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 2-fold increase in the percentage of CD8⁺ single positive thymocytes

hematopoietic system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by more than 5-fold

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is found abundantly in the spleen making up 31% of the splenocyte population

decreased double-positive T cell number ( J:143006 )

• there is about a 2-fold reduction in the percentage of double-positive thymocytes

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 2-fold increase in the percentage of CD8⁺ single positive thymocytes

endocrine/exocrine glands

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by more than 5-fold

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

abnormal T cell differentiation ( J:143006 )

• the pre-arranged TCR genes are expressed abnormally early with intracellular TCR-beta chains detectable in the 75% of the common lymphoid progenitors in the bone marrow

• these TCR-beta chains were also detectable in 35% of multipotent progenitors, 12% of short-term hemopoietic stem cells, and 5% of long-term hemopoietic stem cells of the bone marrow

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is rarely found in the spleen

decreased double-positive T cell number ( J:143006 )

• there is a greater than 4-fold reduction in the percentage of double-positive thymocytes

• the double-positive thymus makes up 83% of the normal thymus but only 16% in these mutants

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 10-fold increase in the percentage of CD8⁺ single positive thymocytes

• the percentage of CD8⁺ T cells among splenocytes is more than double that of controls

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

hematopoietic system

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

abnormal T cell differentiation ( J:143006 )

• the pre-arranged TCR genes are expressed abnormally early with intracellular TCR-beta chains detectable in the 75% of the common lymphoid progenitors in the bone marrow

• these TCR-beta chains were also detectable in 35% of multipotent progenitors, 12% of short-term hemopoietic stem cells, and 5% of long-term hemopoietic stem cells of the bone marrow

abnormal double-negative T cell morphology ( J:143006 )

• there is a severe reduction in the percentage of thymocytes at the DN1-3 stages

• however, there is a large population of unusual double-negative thymocytes that are CD3⁺

• this double-negative CD3⁺ population is rarely found in the spleen

decreased double-positive T cell number ( J:143006 )

• there is a greater than 4-fold reduction in the percentage of double-positive thymocytes

• the double-positive thymus makes up 83% of the normal thymus but only 16% in these mutants

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• the percentage of CD4⁺ T cells in the spleen is reduced to less than a third of that in wild-type

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• there is a 10-fold increase in the percentage of CD8⁺ single positive thymocytes

• the percentage of CD8⁺ T cells among splenocytes is more than double that of controls

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are virtually absent in these mice

endocrine/exocrine glands

thymus hypoplasia ( J:143006 )

• cellularity of the thymus is reduced by about 4-fold

Allelic Composition	Rag2^tm1Fwa/Rag2^tm1Fwa Tcra^Ln3Jae/Tcra⁺ Tcrb^Ln3Jae/Tcrb⁺
Genetic Background	involves: 129S/SvEv * 129S4/SvJae * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rag2^tm1Fwa mutation (45 available); any Rag2 mutation (121 available)
Tcra^Ln3Jae mutation (0 available); any Tcra mutation (101 available)
Tcrb^Ln3Jae mutation (0 available); any Tcrb mutation (97 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up less than 1% of the splenocyte population

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• 99% of T cells in the spleen are CD8⁺ T cells

• 46% of thymocytes are single-positive CD8⁺ cells

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

hematopoietic system

abnormal double-negative T cell morphology ( J:143006 )

• there is a reduction in the percentage of thymocytes at DN1 and DN2 stages while there is a large increase in thymocytes at DN3 and DN4

decreased CD4-positive, alpha-beta T cell number ( J:143006 )

• CD4⁺ T cells make up less than 1% of the splenocyte population

increased CD8-positive, alpha-beta T cell number ( J:143006 )

• 99% of T cells in the spleen are CD8⁺ T cells

• 46% of thymocytes are single-positive CD8⁺ cells

absent gamma-delta T cells ( J:143006 )

• gamma-delta T cells are absent in these mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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