All Phenotypes Kdm1a<tm1.2Tche> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kdm1a^tm1.2Tche
targeted mutation 1.2, Taiping Chen
MGI:3834630

Summary

3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kdm1a^tm1.2Tche/Kdm1a^tm1.2Tche	involves: 129 * C57BL/6	MGI:3834631
ht2	Kdm1a^tm1.2Tche/Kdm1a⁺	involves: 129 * C57BL/6	MGI:7544995
ht3	Kdm1a^tm1.1Tche/Kdm1a^tm1.2Tche	Not Specified	MGI:7544999

Allelic Composition	Kdm1a^tm1.2Tche/Kdm1a^tm1.2Tche
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm1a^tm1.2Tche mutation (0 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and somite formation, complete penetrance ( J:144527 )

• all mice are resorbed by E7.5

embryo

failure to gastrulate ( J:144527 )

embryonic growth arrest ( J:144527 )

• development arrests at or before E5.5 with the egg cylinder failing to elongate and undergo gastrulation

absent egg cylinders ( J:144527 )

cellular

increased apoptosis ( J:144527 )

• in cultured cells

Allelic Composition	Kdm1a^tm1.2Tche/Kdm1a⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm1a^tm1.2Tche mutation (0 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:144527 )

• mice are viable, fertile and exhibit no obvious phenotype

Allelic Composition	Kdm1a^tm1.1Tche/Kdm1a^tm1.2Tche
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm1a^tm1.1Tche mutation (0 available); any Kdm1a mutation (39 available)
Kdm1a^tm1.2Tche mutation (0 available); any Kdm1a mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cardiovascular system

ventricular septal defect ( J:270116 )

• at E18.5, all (4 of 4) mice showed VSDs

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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