Phenotypes associated with this allele

• Allele Symbol: Snph^tm1Zhs
• Allele Name: targeted mutation 1, Zu-Hang Sheng
• Allele ID: MGI:3834635
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Snph^tm1Zhs/Snph^tm1Zhs	involves: 129S6/SvEvTac	MGI:3834647

Genotype
MGI:3834647

hm1

• Allelic Composition: Snph^tm1Zhs/Snph^tm1Zhs
• Genetic Background: involves: 129S6/SvEvTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired coordination ( J:145318 )

• performance on an accelerating rotarod is deficient

• when rotarod speed is held constant, performance is normal

cellular

abnormal mitochondrial morphology ( J:145318 )

• density of mitochondria in axons is reduced

abnormal mitochondrial physiology ( J:145318 )

• motility of mitochondria in neurons is dramatically increased

• velocity of mitochondria in motion is unaffected

nervous system

nervous system phenotype ( J:145318 )

N • amplitude and kinetics of excitatory postsynaptic currents is similar to controls

N • synaptic transmission is unaffected

abnormal synaptic bouton morphology ( J:145318 )

• proportion of presynaptic boutons with nearby mitochondria is significantly reduced

• about 33% of presynaptic boutons contain mitochondria

abnormal neuron physiology ( J:145318 )

• calcium ion buildup at presynaptic terminals under intense stimulation

enhanced paired-pulse facilitation ( J:145318 )

• delivery of high frequency pulse trains to presynaptic neurons results in substantial facilitation followed by depression

• persistent facilitation by application of short stimulus chains at 10 second intervals