Phenotypes associated with this allele

• Allele Symbol: Tnfrsf9^tm1Lpc
• Allele Name: targeted mutation 1, Lieping Chen
• Allele ID: MGI:3834749
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnfrsf9^tm1Lpc/Tnfrsf9^tm1Lpc	B6.129-Tnfrsf9^tm1Lpc	MGI:3834762

Genotype
MGI:3834762

hm1

• Allelic Composition: Tnfrsf9^tm1Lpc/Tnfrsf9^tm1Lpc
• Genetic Background: B6.129-Tnfrsf9^tm1Lpc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:145439 )

N • mice exhibit normal T cell development and polyclonal activation

abnormal memory T cell physiology ( J:145439 )

• when cells are transplanted into congenic Thy1.1 C57BL/6 mice and stimulated with Tnfsf9 antibody, memory T cells fail to expand unlike when wild-type cells are used in the transplant assay

• however, memory T cells response normally to polyI:C and wild-type cells transplanted into mice respond normally toTnfsf9 antibodies

hematopoietic system

abnormal memory T cell physiology ( J:145439 )

• when cells are transplanted into congenic Thy1.1 C57BL/6 mice and stimulated with Tnfsf9 antibody, memory T cells fail to expand unlike when wild-type cells are used in the transplant assay

• however, memory T cells response normally to polyI:C and wild-type cells transplanted into mice respond normally toTnfsf9 antibodies