Analysis Tools
growth/size/body
|
• at 1 to 2 months of age, mice exhibit splenomegaly unlike wild-type mice
• at 5 to 12 months of age, spleen size is 5 times larger than in wild-type mice
• increased connective tissue accounts for splenomegaly
|
|
• in less than 25% of mice, total spleen cell counts are 3-fold higher than in wild-type mice
• however, the remainder of mice exhibit normal spleen cellularity
|
mortality/aging
|
• fertility is decreased at 2 to 3 months of age, and mice are sterile by 5 months of age unlike wild-type mice
|
reproductive system
|
• fertility is decreased at 2 to 3 months of age, and mice are sterile by 5 months of age unlike wild-type mice
|
immune system
|
• at 1 to 2 months of age, mice exhibit splenomegaly unlike wild-type mice
• at 5 to 12 months of age, spleen size is 5 times larger than in wild-type mice
• increased connective tissue accounts for splenomegaly
|
|
• in less than 25% of mice, total spleen cell counts are 3-fold higher than in wild-type mice
• however, the remainder of mice exhibit normal spleen cellularity
|
|
• slight increase
|
|
• B220+ B cells are virtually absent at 4 to 12 months of age
|
|
• slight increase in CD11c+ cells
|
|
• slight increase in NK1.1+ NK cells
|
|
• at 1 month of age in the spleens and lymph nodes
|
|
• at 4 to 12 months, the number of Mac+ cells is increased 3-fold compared to in wild-type mice
|
|
• no B cell follicles are observed in the spleen or lymph nodes while T cell areas are enlarged and less confined
|
|
• at 12 months, splenocytes fail to stimulate proliferative responses or alloreactive cytotoxic T lymphocytes against the allogeneic target EL4 cell line unlike wild-type splenocytes
|
|
• at 85 days IgG levels are one-fifth of normal
|
|
• no B cell follicles are observed in the spleen or lymph nodes while T cell areas are enlarged and less confined
|
hematopoietic system
|
• at 1 to 2 months of age, mice exhibit splenomegaly unlike wild-type mice
• at 5 to 12 months of age, spleen size is 5 times larger than in wild-type mice
• increased connective tissue accounts for splenomegaly
|
|
• in less than 25% of mice, total spleen cell counts are 3-fold higher than in wild-type mice
• however, the remainder of mice exhibit normal spleen cellularity
|
|
• slight increase
|
|
• B220+ B cells are virtually absent at 4 to 12 months of age
|
|
• slight increase in CD11c+ cells
|
|
• slight increase in NK1.1+ NK cells
|
|
• at 1 month of age in the spleens and lymph nodes
|
|
• at 4 to 12 months, the number of Mac+ cells is increased 3-fold compared to in wild-type mice
|
|
• no B cell follicles are observed in the spleen or lymph nodes while T cell areas are enlarged and less confined
|
|
• at 12 months, splenocytes fail to stimulate proliferative responses or alloreactive cytotoxic T lymphocytes against the allogeneic target EL4 cell line unlike wild-type splenocytes
|
|
• at 85 days IgG levels are one-fifth of normal
|
