Phenotypes associated with this allele

• Allele Symbol: Cldn6^tm1(cre)Dkwu
• Allele Name: targeted mutation 1, Doris Wu
• Allele ID: MGI:3834897
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cldn6^tm1(cre)Dkwu/Cldn6^tm1(cre)Dkwu	C57BL/6-Cldn6^tm1(cre)Dkwu	MGI:3844724
cn2	Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6^+	involves: C57BL/6	MGI:5447642
cn3	Atp7a^tm1.1Mjp/Atp7a^+ Cldn6^tm1(cre)Dkwu/Cldn6^+	involves: C57BL/6	MGI:5447643

Genotype
MGI:3844724

hm1

• Allelic Composition: Cldn6^tm1(cre)Dkwu/Cldn6^tm1(cre)Dkwu
• Genetic Background: C57BL/6-Cldn6^tm1(cre)Dkwu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:145443 )

• mice are viable, fertile, and show no gross morphological or behavioral abnormalities

Genotype
MGI:5447642

cn2

• Allelic Composition: Atp7a^tm1.1Mjp/Y; Cldn6^tm1(cre)Dkwu/Cldn6⁺
• Genetic Background: involves: C57BL/6

Developmental and vascular abnormalities in Atp7a^tm1.1Mjp/Y Cldn6^tm1(cre)Dkwu/Cldn6⁺ males

mortality/aging

prenatal lethality, complete penetrance ( J:189931 )

♂ • no mice are born

embryo

decreased embryo size ( J:189931 )

♂ • at E10.5

abnormal tail bud morphology ( J:189931 )

♂ • abnormal orientation at E10.5

pale yolk sac ( J:189931 )

♂

craniofacial

abnormal frontonasal prominence morphology ( J:189931 )

♂ • at E10.5

growth/size/body

decreased embryo size ( J:189931 )

♂ • at E10.5

integument

pallor ( J:189931 )

♂ • embryos lack blood-filled vascular network

limbs/digits/tail

abnormal tail bud morphology ( J:189931 )

♂ • abnormal orientation at E10.5

Genotype
MGI:5447643

cn3

• Allelic Composition: Atp7a^tm1.1Mjp/Atp7a⁺; Cldn6^tm1(cre)Dkwu/Cldn6⁺
• Genetic Background: involves: C57BL/6

Patches of hypopigmentation in coats of Atp7a^tm1.1Mjp/Atp7a⁺ Cldn6^tm1(cre)Dkwu/Cldn6⁺ females

mortality/aging

postnatal lethality, incomplete penetrance ( J:189931 )

♀ • only two mice survive beyond the second day after birth

prenatal lethality, incomplete penetrance ( J:189931 )

♀ • fewer than expected mice are born

integument

curly vibrissae ( J:189931 )

♀

pigmentation

hypopigmentation ( J:189931 )

♀ • mosaic pattern of hypopigmented coat coloring in surviving mice