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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Socs3tm1Robb
targeted mutation 1, Lorraine Robb
MGI:3835162
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Socs3tm1Robb/Socs3tm1Robb involves: C57BL/6 MGI:3835184


Genotype
MGI:3835184
hm1
Allelic
Composition
Socs3tm1Robb/Socs3tm1Robb
Genetic
Background
involves: C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Socs3tm1Robb mutation (0 available); any Socs3 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• typically enlarged
• becomes significantly enlarged relative to controls after 5 days of injections with G-CSF
• blood progenitor cell mobilization significantly increased relative to controls after 5 days of injections with G-CSF
• develops with time
• numbers become significantly increased relative to controls after 5 days of injections with G-CSF
• cells in culture respond to G-CSF or Il-6 with an increase in colony forming cells
• no increase in macrophage colonies

skeleton
• induced by intra-articular injection of methylated bovine serum albumin followed by three daily subcutaneous Il-1 injections

immune system
• typically enlarged
• becomes significantly enlarged relative to controls after 5 days of injections with G-CSF
• develops with time
• numbers become significantly increased relative to controls after 5 days of injections with G-CSF
• induced by intra-articular injection of methylated bovine serum albumin followed by three daily subcutaneous Il-1 injections

growth/size/body
• typically enlarged
• becomes significantly enlarged relative to controls after 5 days of injections with G-CSF





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/12/2024
MGI 6.24
The Jackson Laboratory