Phenotypes associated with this allele

• Allele Symbol: Tg(Gata1-Epor)AMym
• Allele Name: transgene insertion A, Masayuki Yamamoto
• Allele ID: MGI:3835185
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Epor^tm1Lizon/Epor^tm1Lizon Tg(Gata1-Epor)AMym/0	involves: 129S4/SvJae * C57BL/6 * DBA	MGI:3835194

Genotype
MGI:3835194

cx1

• Allelic Composition: Epor^tm1Lizon/Epor^tm1Lizon; Tg(Gata1-Epor)AMym/0
• Genetic Background: involves: 129S4/SvJae * C57BL/6 * DBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:121500 )

• survival is significantly impaired under chronic hypoxia conditions compared to similarly treated wild-type mice

• however, under normoxic conditions mice exhibit normal survival unlike in Epor^tm1Liz homozygotes

cardiovascular system

abnormal lung vasculature morphology ( J:121500 )

• under hypoxic conditions, muscularization of pulmonary small-vessels is accelerated compared to in similarly treated wild-type mice

abnormal physiological neovascularization ( J:82257 )

• in a model of retinopathy of prematurity (ROP), mutants exhibit fewer numbers of vascular tubes that reach into the inner nuclear layer at P17, indicating reduced neovascularization in the retina after hypoxic conditions

abnormal vascular endothelial cell migration ( J:121500 )

• under hypoxic conditions, mobilization of endothelial precursor cells is impaired and fewer CD31+ cells migrate to the pulmonary endothelium than in similarly treated wild-type mice

heart right ventricle hypertrophy ( J:121500 )

• accelerated under hypoxic conditions

abnormal heart right ventricle pressure ( J:121500 )

• under hypoxic conditions, right ventricle systolic pressure is increased compared to in similarly treated wild-type mice

pulmonary hypertension ( J:121500 )

• development of pulmonary hypertension is accelerated under hypoxic conditions as measured by right ventricle systolic pressure and right ventricle hypertrophy compared to in wild-type mice

• however, irradiated mice transplanted with wild-type bone marrow exhibit a partial rescue in the development of pulmonary hypertension

respiratory system

abnormal lung vasculature morphology ( J:121500 )

• under hypoxic conditions, muscularization of pulmonary small-vessels is accelerated compared to in similarly treated wild-type mice

homeostasis/metabolism

abnormal response to injury ( J:121500 )

• survival is significantly impaired under chronic hypoxia conditions compared to similarly treated wild-type mice

• under hypoxic conditions, right ventricle systolic pressure is increased and right ventricle hypertrophy is accelerated compared to in similarly treated wild-type mice

• under hypoxic conditions, muscularization of pulmonary small-vessels is accelerated compared to in similarly treated wild-type mice

• under hypoxic conditions, mobilization of endothelial precursor cells is impaired and fewer CD31+ cells migrate to the pulmonary endothelium than in similarly treated wild-type mice

cellular

abnormal vascular endothelial cell migration ( J:121500 )

• under hypoxic conditions, mobilization of endothelial precursor cells is impaired and fewer CD31+ cells migrate to the pulmonary endothelium than in similarly treated wild-type mice

growth/size/body

heart right ventricle hypertrophy ( J:121500 )

• accelerated under hypoxic conditions

muscle

heart right ventricle hypertrophy ( J:121500 )

• accelerated under hypoxic conditions