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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock8pri
primurus
MGI:3835421
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock8pri/Dock8pri C57BL/6JAnu-Dock8pri MGI:4415049
hm2
 		Dock8pri/Dock8pri involves: C57BL/6JAnu MGI:6140059
ht3
 		Dock8cpm/Dock8pri C57BL/6J-Dock8cpm/Dock8pri MGI:4415050


Genotype
MGI:4415049
hm1
Allelic
Composition		 Dock8pri/Dock8pri
Genetic
Background		 C57BL/6JAnu-Dock8pri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8pri mutation (4 available); any Dock8 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased germinal center B cell number ( J:155516 )
• 15% of normal after immunization
decreased B-1 B cell number ( J:155516 )
• the frequency of B-1 B cells in the peritoneal cavity is 60% lower than in wild-type mice
decreased marginal zone B cell number ( J:155516 )
• near absent and not corrected by overexpression of BAFF (Tnfsf13b)
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice
decreased spleen germinal center size ( J:155516 )
• after immunization with sheep red blood cells

immune system
decreased germinal center B cell number ( J:155516 )
• 15% of normal after immunization
decreased B-1 B cell number ( J:155516 )
• the frequency of B-1 B cells in the peritoneal cavity is 60% lower than in wild-type mice
decreased marginal zone B cell number ( J:155516 )
• near absent and not corrected by overexpression of BAFF (Tnfsf13b)
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice
decreased spleen germinal center size ( J:155516 )
• after immunization with sheep red blood cells
abnormal humoral immune response ( J:155516 )
• with or without booster immunization, mice exhibit defective maturation phase of the antibody response initiated by killed Bordetella pertussis bacteria or antigen chicken gamma-globulin (CGG) unlike wild-type mice
• in response to exposure to CGG, mice fail to develop antibodies against azobenzenearsonate unlike similarly treated wild-type mice




Genotype
MGI:6140059
hm2
Allelic
Composition		 Dock8pri/Dock8pri
Genetic
Background		 involves: C57BL/6JAnu
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8pri mutation (4 available); any Dock8 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal cellular extravasation ( J:238772 )
• reduced migration of encephalitogenic CD4+ T cells from MOG-treated mice, suffering from experimental autoimmune encephalomyelitis, into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated heterozygous mutant mice

hematopoietic system
abnormal cellular extravasation ( J:238772 )
• reduced migration of encephalitogenic CD4+ T cells from MOG-treated mice, suffering from experimental autoimmune encephalomyelitis, into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated heterozygous mutant mice

immune system
abnormal cellular extravasation ( J:238772 )
• reduced migration of encephalitogenic CD4+ T cells from MOG-treated mice, suffering from experimental autoimmune encephalomyelitis, into CNS when transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated heterozygous mutant mice
decreased susceptibility to experimental autoimmune encephalomyelitis ( J:238772 )
• reduced clinical scores after MOG (35-55) peptide-induced EAE
• encephalitogenic CD4+ T cells from MOG-treated mice fail to cause disease when transplanted into sub-lethally irradiated WT recipient mice

nervous system
abnormal myelination ( J:238772 )
• reduced demyelination in spinal cord after encephalitogenic CD4+ T cells from MOG-treated mice, suffering from experimental autoimmune encephalomyelitis, are transplanted into sub-lethally irradiated WT recipient mice, compared to same cells transplanted from MOG-treated heterozygous mutant mice
• reduced demyelination in spinal cord after MOG peptide-induced experimental autoimmune encephalomyelitis compared to MOG-treated heterozygous mutant mice




Genotype
MGI:4415050
ht3
Allelic
Composition		 Dock8cpm/Dock8pri
Genetic
Background		 C57BL/6J-Dock8cpm/Dock8pri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8cpm mutation (4 available); any Dock8 mutation (103 available)
Dock8pri mutation (4 available); any Dock8 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice

immune system
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory