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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Dock8cpm
captain morgan
MGI:3835422
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Dock8cpm/Dock8cpm C57BL/6JSfdAnu-Dock8cpm MGI:4415048
ht2
 		Dock8cpm/Dock8pri C57BL/6J-Dock8cpm/Dock8pri MGI:4415050


Genotype
MGI:4415048
hm1
Allelic
Composition		 Dock8cpm/Dock8cpm
Genetic
Background		 C57BL/6JSfdAnu-Dock8cpm
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8cpm mutation (4 available); any Dock8 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice
decreased spleen germinal center size ( J:155516 )
• after immunization with sheep red blood cells

immune system
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice
decreased spleen germinal center size ( J:155516 )
• after immunization with sheep red blood cells
abnormal humoral immune response ( J:155516 )
• with or without booster immunization, mice exhibit defective maturation phase of the antibody response initiated by killed Bordetella pertussis bacteria or antigen chicken gamma-globulin (CGG) unlike wild-type mice
• in response to exposure to CGG, mice fail to develop antibodies against azobenzenearsonate unlike similarly treated wild-type mice




Genotype
MGI:4415050
ht2
Allelic
Composition		 Dock8cpm/Dock8pri
Genetic
Background		 C57BL/6J-Dock8cpm/Dock8pri
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dock8cpm mutation (4 available); any Dock8 mutation (103 available)
Dock8pri mutation (4 available); any Dock8 mutation (103 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice

immune system
decreased T cell number ( J:155516 )
• naive T cells are 50% lower than in wild-type mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory