All Phenotypes Erbb3<tm3Cbm> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Erbb3^tm3Cbm
targeted mutation 3, Carmen Birchmeier
MGI:3835516

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ	MGI:3835562
cn2	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5588163
cn3	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0	involves: 129P2/OlaHsd * C57BL/6 * FVB/N	MGI:5588164
cn4	Erbb3^tm3Cbm/Erbb3^tm3Cbm Tg(Dhh-cre)1Mejr/0	involves: 129P2/OlaHsd * FVB/N	MGI:5588162

Allelic Composition	Erbb3^tm2Cbm/Erbb3^tm3Cbm Erbb4^tm1Fej/Erbb4^tm1Fej Cnp^tm1(cre)Kan/?
Genetic Background	involves: 129P2/OlaHsd * 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cnp^tm1(cre)Kan mutation (0 available); any Cnp mutation (27 available)
Erbb3^tm2Cbm mutation (0 available); any Erbb3 mutation (48 available)
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (48 available)
Erbb4^tm1Fej mutation (1 available); any Erbb4 mutation (87 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:145464 )

• develop to term but die in the second post natal week

nervous system

nervous system phenotype ( J:145464 )

N	• central nervous system myelination is normal up to 11 days of age (optic nerve and corpus callosum)

abnormal myelination ( J:145464 )

• severely defective myelination in the peripheral nervous system

Allelic Composition	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (48 available)
Gt(ROSA)26Sor^{tm8(Map2k1*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased myelin sheath thickness ( J:207470 )

• at P15, the myelin of peripheral axons is thinner but axons are hypermyelinated at P90

abnormal myelination ( J:207470 )

• at P15 and P90, 36.7% and 17.8% of axons with diameters >1 um are nonmyelinated, respectively compared to 3.5% and 0.8% in controls

hypermyelination ( J:207470 )

• axons are hypermyelinated at P90

• however, mice show rescue of Schwann cell development and Schwan cells are able to myelinate

Allelic Composition	Erbb3^tm3Cbm/Erbb3^tm3Cbm Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky}/? Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (48 available)
Gt(ROSA)26Sor^{tm7(Pik3ca*,EGFP)Rsky} mutation (1 available); any Gt(ROSA)26Sor mutation (993 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal myelination ( J:207470 )

• myelination is not seen

Allelic Composition	Erbb3^tm3Cbm/Erbb3^tm3Cbm Tg(Dhh-cre)1Mejr/0
Genetic Background	involves: 129P2/OlaHsd * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Erbb3^tm3Cbm mutation (0 available); any Erbb3 mutation (48 available)
Tg(Dhh-cre)1Mejr mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

absent Schwann cells ( J:207470 )

• almost complete absence of Schwann cells

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/19/2024 MGI 6.24