Phenotypes associated with this allele

• Allele Symbol: Kmt2e^tm1Nik
• Allele Name: targeted mutation 1, Nigel Killeen
• Allele ID: MGI:3835592
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Kmt2e^tm1Nik/Kmt2e^tm1Nik	B6.Cg-Kmte^tm1Nik	MGI:3835662

Genotype
MGI:3835662

hm1

• Allelic Composition: Kmt2e^tm1Nik/Kmt2e^tm1Nik
• Genetic Background: B6.Cg-Kmte^tm1Nik

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:145449 )

• 70% of mice die before weaning age

neonatal lethality, incomplete penetrance ( J:145449 )

• most die within the first 24 hours of birth

growth/size/body

postnatal growth retardation ( J:145449 )

• mice that survive past weaning show mild growth retardation

• surviving mice are otherwise healthy

hematopoietic system

hematopoietic system phenotype ( J:145449 )

N • all hematopoietic cells present in near normal proportions in peripheral blood

N • no spontaneous hematological disease over 1 year of observation

abnormal definitive hematopoiesis ( J:145449 )

• spleen cell colony formation after transplantation to irradiated hosts is normal after 8 days but severely reduced after 12 days

• competitive repopulation tests show a moderate under-representation of mutant cells at 4 weeks

• competitive repopulation tests show a significant under-representation of mutant cells at 3 months

increased neutrophil cell number ( J:145449 )

• somewhat elevated in the circulation but not in bone marrow

decreased NK cell number ( J:145449 )

• significantly reduced, particularly in the liver

decreased NK T cell number ( J:145449 )

• significantly reduced, particularly in the liver

abnormal hematopoietic stem cell morphology ( J:145449 )

• normal numbers of multipotent progenitor cells derived from short-term repopulating stem cells

• granulocyte/macrophage progenitors are reduced

• megakaryocyte/erythrocyte progenitors are increased in number

• significantly reduced number of common lymphoid progenitors

decreased hematopoietic stem cell number ( J:145449 )

• 30% reduction in long-term repopulating hematopoietic stem cells

increased hematopoietic stem cell number ( J:145449 )

• increased numbers of short-term repopulating stem cells

immune system

increased neutrophil cell number ( J:145449 )

• somewhat elevated in the circulation but not in bone marrow

decreased NK cell number ( J:145449 )

• significantly reduced, particularly in the liver

decreased NK T cell number ( J:145449 )

• significantly reduced, particularly in the liver