About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Elp1Gt(BGB184)Byg
gene trap BGB184, BayGenomics
MGI:3835595
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Elp1Gt(BGB184)Byg/Elp1Gt(BGB184)Byg B6.129P2-Gt(BGB184)Byg MGI:3835654


Genotype
MGI:3835654
hm1
Allelic
Composition
Elp1Gt(BGB184)Byg/Elp1Gt(BGB184)Byg
Genetic
Background
B6.129P2-Gt(BGB184)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp1Gt(BGB184)Byg mutation (0 available); any Elp1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no embryos are recovered at E12.5
• however, embryonic lethality can be rescued by over-expression of human IKBKAP

embryo
• at E9.5, only a primary capillary plexus has developed in the visceral yolk sac unlike in wild-type mice
• at E9.5 to E10, development is arrested at the late egg cylinder stage
• mice exhibit no further development after E10.5
• by E7.5 and E9.5, extraembryonic components are smaller than in wild-type mice
• at E10.5
• at E9.5, no visible primitive nucleated red blood cells are observed unlike in wild-type mice

cardiovascular system
• at E9.5 and E10, mice lack blood vessels unlike in wild-type mice
• at E9.5, only a primary capillary plexus has developed in the visceral yolk sac unlike in wild-type mice

nervous system
• at E10.5, brain structures are absent with the mid- and hindbrain wall-like structures irregularly aligned unlike in wild-type mice

growth/size/body

limbs/digits/tail
• at E10.5

craniofacial

hematopoietic system
• at E9.5, no visible primitive nucleated red blood cells are observed unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hemophagocytic lymphohistiocytosis DOID:0050120 OMIM:PS267700
J:145561





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
11/12/2024
MGI 6.24
The Jackson Laboratory