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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Elp1Gt(BGB184)Byg
gene trap BGB184, BayGenomics
MGI:3835595
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Elp1Gt(BGB184)Byg/Elp1Gt(BGB184)Byg B6.129P2-Gt(BGB184)Byg MGI:3835654


Genotype
MGI:3835654
hm1
Allelic
Composition
Elp1Gt(BGB184)Byg/Elp1Gt(BGB184)Byg
Genetic
Background
B6.129P2-Gt(BGB184)Byg
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elp1Gt(BGB184)Byg mutation (0 available); any Elp1 mutation (69 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• no embryos are recovered at E12.5
• however, embryonic lethality can be rescued by over-expression of human IKBKAP

embryo
• at E9.5, only a primary capillary plexus has developed in the visceral yolk sac unlike in wild-type mice
• at E9.5 to E10, development is arrested at the late egg cylinder stage
• mice exhibit no further development after E10.5
• by E7.5 and E9.5, extraembryonic components are smaller than in wild-type mice
• at E10.5
• at E9.5, no visible primitive nucleated red blood cells are observed unlike in wild-type mice

cardiovascular system
• at E9.5 and E10, mice lack blood vessels unlike in wild-type mice
• at E9.5, only a primary capillary plexus has developed in the visceral yolk sac unlike in wild-type mice

nervous system
• at E10.5, brain structures are absent with the mid- and hindbrain wall-like structures irregularly aligned unlike in wild-type mice

growth/size/body

limbs/digits/tail
• at E10.5

craniofacial

hematopoietic system
• at E9.5, no visible primitive nucleated red blood cells are observed unlike in wild-type mice

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
hemophagocytic lymphohistiocytosis DOID:0050120 OMIM:PS267700
J:145561





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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
10/29/2024
MGI 6.24
The Jackson Laboratory