mortality/aging
• no embryos are recovered at E12.5
• however, embryonic lethality can be rescued by over-expression of human IKBKAP
|
embryo
• at E9.5, only a primary capillary plexus has developed in the visceral yolk sac unlike in wild-type mice
|
• at E10.5
|
• at E9.5 to E10, development is arrested at the late egg cylinder stage
• mice exhibit no further development after E10.5
|
• at E7.5
|
• by E7.5 and E9.5, extraembryonic components are smaller than in wild-type mice
|
• at E10.5
|
• at E10.5
|
• at E7.5
|
• at E9.5, no visible primitive nucleated red blood cells are observed unlike in wild-type mice
|
cardiovascular system
• at E9.5 and E10, mice lack blood vessels unlike in wild-type mice
|
• at E9.5, only a primary capillary plexus has developed in the visceral yolk sac unlike in wild-type mice
|
nervous system
• at E10.5, brain structures are absent with the mid- and hindbrain wall-like structures irregularly aligned unlike in wild-type mice
|
growth/size/body
• at E7.5
|
limbs/digits/tail
• at E10.5
|
craniofacial
• at E10.5
|
hematopoietic system
• at E9.5, no visible primitive nucleated red blood cells are observed unlike in wild-type mice
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
hemophagocytic lymphohistiocytosis | DOID:0050120 |
OMIM:PS267700 |
J:145561 |