Phenotypes associated with this allele

• Allele Symbol: Tnip1^tm1.1Ama
• Allele Name: targeted mutation 1.1, Averil Ma
• Allele ID: MGI:3835790
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tnip1^tm1.1Ama/Tnip1^tm1.1Ama	involves: C57BL/6J	MGI:3835805
cx2	Tnf^tm1Ljo/Tnf^tm1Ljo Tnip1^tm1.1Ama/Tnip1^tm1.1Ama	involves: 129S1/Sv * C57BL/6J	MGI:3835806
cx3	Tnf^tm1Ljo/Tnf^+ Tnip1^tm1.1Ama/Tnip1^tm1.1Ama	involves: 129S1/Sv * C57BL/6J	MGI:3835807

Genotype
MGI:3835805

hm1

• Allelic Composition: Tnip1^tm1.1Ama/Tnip1^tm1.1Ama
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:145539 )

• despite normal Mendelian ratios at E18.5, fewer than expected mice are born alive

liver/biliary system

increased hepatocyte apoptosis ( J:145539 )

• fetal livers exhibit patches of hypocellularity due to increased apoptosis compared to in wild-type mice

liver hypoplasia ( J:145539 )

• fetal livers exhibit patches of hypocellularity due to increased apoptosis compared to in wild-type mice

hematopoietic system

anemia ( J:145539 )

• at E18.5

decreased hematocrit ( J:145539 )

• at E18.5

cellular

increased fibroblast apoptosis ( J:145539 )

• mouse embryonic fibroblasts treated with TNF and CHX exhibit increased apoptosis compared to similarly treated wild-type cells

• however, apoptosis could be blocked by treatment with ZVAD or exctopic expression of TNIP1

increased hepatocyte apoptosis ( J:145539 )

• fetal livers exhibit patches of hypocellularity due to increased apoptosis compared to in wild-type mice

growth/size/body

decreased fetal size ( J:145539 )

• at E16.5 and E18.5, fetal size is reduced compared to in wild-type mice

decreased fetal weight ( J:145539 )

• at E18.5, fetal weight is reduced compared to in wild-type mice

integument

pallor ( J:145539 )

• at E16.5 and E18.5

Genotype
MGI:3835806

cx2

• Allelic Composition: Tnf^tm1Ljo/Tnf^tm1Ljo; Tnip1^tm1.1Ama/Tnip1^tm1.1Ama
• Genetic Background: involves: 129S1/Sv * C57BL/6J

mortality/aging

mortality/aging ( J:145539 )

N • mice are born in Mendelian ratio

Genotype
MGI:3835807

cx3

• Allelic Composition: Tnf^tm1Ljo/Tnf⁺; Tnip1^tm1.1Ama/Tnip1^tm1.1Ama
• Genetic Background: involves: 129S1/Sv * C57BL/6J

mortality/aging

perinatal lethality, incomplete penetrance ( J:145539 )

• fewer than expected mice are born alive