Phenotypes associated with this allele

• Allele Symbol: Rad18^tm1Stat
• Allele Name: targeted mutation 1, Satoshi Tateishi
• Allele ID: MGI:3835812
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Rad18^tm1Stat/Rad18^tm1Stat	B6.Cg-Rad18^tm1Stat	MGI:3835820

Genotype
MGI:3835820

hm1

• Allelic Composition: Rad18^tm1Stat/Rad18^tm1Stat
• Genetic Background: B6.Cg-Rad18^tm1Stat

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal spermatogonia morphology ( J:145534 )

♂ • degenerating tubules lack early-differentiated-phase germ cells

decreased male germ cell number ( J:145534 )

♂ • male germ cells are progressively lost with age

♂ • at 6 months, 10% of seminiferous tubules lack germ line cells and consist of only Sertoli cells unlike in wild-type mice

♂ • degenerating tubules lack early-differentiated-phase germ cells

reproductive system

abnormal spermatogonia morphology ( J:145534 )

♂ • degenerating tubules lack early-differentiated-phase germ cells

decreased male germ cell number ( J:145534 )

♂ • male germ cells are progressively lost with age

♂ • at 6 months, 10% of seminiferous tubules lack germ line cells and consist of only Sertoli cells unlike in wild-type mice

♂ • degenerating tubules lack early-differentiated-phase germ cells

seminiferous tubule degeneration ( J:145534 )

♂ • at 12 months, one-quarter of seminiferous tubules exhibit degeneration unlike in wild-type mice

♂ • degenerating tubules lack early-differentiated-phase germ cells

♂ • however, Sertoli cells from degenerating seminiferous tubules support spermatogenesis in transplant assays

decreased testis weight ( J:145534 )

♂ • testes weight decreases with age and is 84% and 60% of wild-type at 6 and 12 months, respectively

♂ • however, seminal vesicle weights are normal

reduced male fertility ( J:145534 )

♂ • male fertility declines with age and is less than in wild-type mice at 12 months

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:145534 )

N • follicle-stimulating hormone and testosterone concentrations are normal

endocrine/exocrine glands

seminiferous tubule degeneration ( J:145534 )

♂ • at 12 months, one-quarter of seminiferous tubules exhibit degeneration unlike in wild-type mice

♂ • degenerating tubules lack early-differentiated-phase germ cells

♂ • however, Sertoli cells from degenerating seminiferous tubules support spermatogenesis in transplant assays

decreased testis weight ( J:145534 )

♂ • testes weight decreases with age and is 84% and 60% of wild-type at 6 and 12 months, respectively

♂ • however, seminal vesicle weights are normal