Analysis Tools|
Allele Symbol Allele Name Allele ID |
Tg(Slc6a3-cre/ERT2)1Span transgene insertion 1, Rainer Spanagel MGI:3835856 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants
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• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice to a similar level as seen in single conditional Rrn3 mutants
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• tamoxifen-treated mice exhibit normal anxiety-related behavior, behavior in a forced swim test, and auditory fear conditioning
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| N |
• tamoxifen-treated mice exhibit normal basal and stress-induced corticosterone levels
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• abnormally enlarged nerve terminals are seen in mice 4 weeks after treatment with tamoxifen at 4 weeks of age, showing fewer synaptic vesicles at active zones and an increase in the number of autophagic-lysosomal vesicles
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• striatal expression of dopamine transporter (DAT) is reduced in the ventral striatum 18 months after tamoxifen treatment indicating dopaminergic neuron loss, however, no loss of TH or DAT expression in the dorsal striatum and no loss of TH+ cells are seen at this time point
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• dopamine and its metabolites are diminished after tamoxifen treatment of 4 week old mice
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• motor dysfunction in mice injected with tamoxifen at 2 months of age
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• nucleolar integrity is disrupted in dopaminergic neurons of tamoxifen treated mice
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• about 40% decrease in COX activity is seen 2 weeks after tamoxifen treatment, indicating mitochondrial damage is an early consequence of nucleolar damage
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• induction of nucleolar stress is seen in dopaminergic neurons of tamoxifen treated mice
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• dopaminergic neurons of tamoxifen-induced mice are more vulnerable to the oxidative damage induced by MPTP than controls showing an approximate 40% loss of neurons compared to 15% in controls
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• dopaminergic neurons show higher levels of oxidative stress markers at 4 weeks after tamoxifen treatment
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• mice injected with tamoxifen at 2 months of age exhibit a decline in dopamine content in the striatum
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• mice injected with tamoxifen at 2 months of age show a progressive differential loss of dopaminergic neurons in substantia nigra and ventral tegmental area
• tamoxifen-induced mice treated with pifithrin-alpha, a chemical inhibitor of Trp53 show prevention of dopaminergic neuron loss
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• mice injected with tamoxifen at 2 months of age exhibit neurodegeneration of TH+ neurons
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease | DOID:14330 |
OMIM:PS168600 |
J:168232 , J:242309 | |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 11/12/2024 MGI 6.24 |
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